Group leader: Constantina Heltianu, PhD
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Senior investigator, PhD
Supervisor in Cellular and Molecular Biology
Advisor graduate and master thesis program
Member of the Scientific Council
Research Fellow, Fulbright Fellowship Yale Univ.,
Visiting Scientist, MRC,
Expert in Romanian Committee FP7 Health Programme
Evaluator at the Romanian Research Programs and international journals
Major research interests
Histamine receptors of the microvascular endothelium
Spectrin and fodrin-like proteins in endothelial cells
Transport of plasma hormones and macromolecules through endothelial cells
Protein and lipid composition of the membrane microdomains of endothelial cells
Gene polymorphisms in atherosclerosis, diabetes mellitus, obesity, metabolic syndrome and ageing
Role of endothelin and nitric oxide in diseases characterized by endothelial dysfunction
Lysosomal enzymes in cells involved in atherosclerosis
Junctional proteins at the endothelial cell-cell contactTechnical expertise
Cell biology methods: experimental animals, cell culture (endothelial cells, smooth muscle cells), microscopy (optic, fluorescence and electron microscopy), immunocyto-chemistry, protein labeling, scintillation counting, autoradiography, immunochemical methods, western blotting, DNA and protein electrophoresis, gel and affinity chromatography, spectrophotometry and spectrofluorimetry; Molecular biology methods: nucleic acids isolation and purification, PCR, RFLP-PCR, quantitative Real Time PCR, gene cloning, plasmid constructs, DNA and silencing RNA transfection, decoy oligodeoxynucleotides, transcription factor analysis (chromatin immunoprecipitation).
Publications
53 original scientific articles, 4 book chapters - ISI citations: 335
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