| Staff | Head
Ileana Manduteanu, Ph.D.
Manuela Calin, Ph.D.
Elena Dragomir, Ph.D.
Ana-Maria Gan, Ph.D. student
Stan Daniela, Ph.D. student
Monica Pirvulescu, Research Assistant
Viorel Simion, Research Assistant
Gabriela Mesca, Technical assistant
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| Ileana Manduteanu | 
Ileana Manduteanu, Ph.D.
Major positions
- Member of the Scientific Council
- Visiting scientist: Institute of Pharmacological Research, "Mario Negri", Milan, Italy
- Teaching activity: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania
- Expert national grant evaluator
Major research interest of the laboratory
- Structural- functional characteristics of valvular endothelial cells and their alteration in diseases.
- Interaction of endothelial cells and smooth muscle cells w
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| Previous Projects | In collaboration with former research staff:
Cristina Lupu, Maria Calb, Florea Lupu, Aurelian Radu, Geo Serban
Surface alteration of blood platelets in diabetes mellitus
The outer surface of the human blood platelets is rich in carbohydrates, which are believed to be responsible for the highly aggregating nature of these cells, and also for the interactions with the vessel wall (F. Lupu et al. 1988).
In diabetes, the distribution of some proteoglycans, anionic sites and carbohydrate moieties ...
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| Current Projects | | Molecular links between chronic inflammation and accelerated atherosclerosis: role of resistin and of chemokines (fractalkine and CXCL16); new avenues for targeted therapy
Current evidence supports a central role of inflammatory processes in all phases of atherosclerosis, but the underlying molecular mechanisms are incompletely understood.
We hypothesize that resistin (a newly discovered cytokine with an unclear function in humans), fractalkine and CXCL16 (chemokines and cell adhesion molecule ...
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| Selected Publications | | Manduteanu I., Dragomir E., Calin M., Gan A.M., Stan D., Pirvulescu M., Simionescu M. Resistin up-regulates fractalkine expression in human endothelial cells; lack of additive effect with TNF-alpha. Biochemical and Biophysical Research Commun, BBRC, 381, 95-101, 2009.
Voinea Calin M., Manduteanu I, Dragomir E., Dragan E., Nicolae M., Gan A. M., Simionescu M., Effect of monocytes/macrophages depletion on early aortic valve lesion in experimental hyperlipidemia. Cell and Tissue Research 336(2):23 ...
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