Laboratories
Molecular Biology and Gene Regulation
| Staff | Group leader
Anca Violeta Gafencu, PhD
Madalina Fenyo, Ph.D. student
Violeta Trusca, Ph.D. student
Irina Florea, Master student
Floarea Georgescu, Technical assistant |
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| Anca V. Gafencu | Anca V. Gafencu, Ph.D.
Major position and appointments
Member of the Scientific Council
Advisor Master program
Visiting scientist Univ. Lausanne, Univ. Crete Medical School, Greece, Univ. Patras, Greece
Executive manager of INCO project “Centre of Excellence” (2001-2005), FP5 grant ICA1-CT-2000-70020, coordinator Dr. M. Simionescu
Executive Manager of the SERA project (2005-2008), FP6 SSA grant 016873/2005, coordinator Dr. M. Simionescu.
MAJOR RESEARCH INTERESTS OF THE GROUP
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| Previous Projects | PREVIOUS PROJECTS
The structure of endothelial caveolae
Different microdomains were isolated from a highly purified endothelial cells (EC) apical membrane fraction and identified by their protein markers. The caveolar membrane fraction was morphologically and biochemically characterized (electron microscopy, protein and lipid assays). The results obtained revealed differential distribution of various proteins and fatty acids in caveolar and non-caveolar domains (A.V. Gafencu et al., 1998).
Isol...
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| Current Projects | CURRENT PROJECTS
“Modulation of gene expression and molecular engineering for development of novel therapeutic anti-atherosclerotic strategies”
Gene regulation of apolipoproteins belonging to the apoE/apoCI/apoCIV/apoCII cluster
The major goal of the project is the understanding of the molecular mechanisms of apolipoproteins gene regulation in normal conditions and the identification of the alteration that affect the gene expression in pathological states.
Apolipoprotein E (apoE), a glycoprotei
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