icbp

Laboratories Vascular Dysfunction in Diabetes and Obesity

Staff

Head
Doina Popov, Ph.D.
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Adriana Georgescu, Ph.D.
Gabriela Costache, Ph.D.
Nicoleta Alexandru, Ph.D.
Alina Constantin, Ph.D. student
Madalina Dumitrescu, Ph.D. student
Miruna Nemecz, Ph.D. student
Delia Ionita, Research assistant
Marilena Isachi, Technical assistant
Marcela Toader, Technical assistant

Doina Popov

Major position and appointments

Associate Member of the Romanian Academy

Scientific Secretary and Member of the Scientific Council of ICBP

Ph.D. Advisor in Biology; Advisor Graduate and Master Students

Fulbright Fellow at New York University, Medical Center, New York, USA

Visiting Scientist: Yale University, New Haven, USA; University of Aarhus, Dept. of Pharmacology, Aarhus, Denmark; University College London, Department of Biochemistry and Molecular Biology, London, UK

Expe

Previous Projects

In collaboration with former research staff:
Nicolae Ghinea, Lucian Ghitescu, Zorina Galis, Mirela Hasu, Carmen Cristea, Alexandrina Vulpanovici, Mirela Enache, Virgil Muresan, Mircea Leabu, Junona Moroianu

Biochemical Mapping of Endothelial Cell Surface: Evidence for Differentiated Microdomains

The first demonstration on the existence of differentiated microdomains on endothelial cell membrane by Maya Simionescu, Nicolae Simionescu and George E. Palade conducted to new experiments employing
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Current Projects

Metabolic dysregulation, a common mechanism in Metabolic Syndrome - related disorders: insulin resistance, obesity, hypertension, and hypercoagulability

Effect of high glucose concentration on signaling proteins activation in human aortic SMCs; the regulatory role of Protein Tyrosine Phosphatase-1B

In hyperglycemia-induced signaling dysregulation of vascular SMCs, a major role has the activation of phosphorylation cascades, regulated by dephosphorylation reactions exerted by phosphatases. On

Selected Publications

Simionescu M., Popov D., Sima A., Endothelial transcytosis in health and disease. Cell Tissue Res 335:27-40, 2009.

Popov D., Vascular PTPs: Current developments and challenges for exploitation on Type 2 diabetes-associated vascular dysfunction, Biochem Biophys Res Commun , 389: 1-4, 2009.

Popov D., Nemecz M., Dumitrescu M., Georgescu A., Böhmer F. D. Long-term high glucose concentration influences Akt, ERK1/2, and PTP1B protein expression in human aortic smooth muscle cells, Biochem Bio

Current Collaborations

Prof. Juan Antonio Rosado, Department of Physiology (Cell Physiology Research Group), University of Extremadura, Cáceres. Spain
Prof. Frank Dietmar Böhmer, Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Friederich Schiller University, Jena, Germany
INSERM (French Institute of Health and Medical Research), Cardiovascular Research Center at Lariboisiere,
Prof. Shlomo Sasson, Dept.of Pharmacology, Hebrew University-Faculty of Medicine, Jerusalem, Israel
Institute o