About us
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Departamentul de Patofiziologie si Farmacologie
PERSPECTIVES
The major goal of the further studies is to understand the signalling dysregulation and to identify the dysfunctional molecules of vascular cells in pathologies such as diabetes mellitus, obesity, hypercholesterolemia and hypertension. Such molecules may be further tailored into new generation of drugs able to ameliorate the impact of metabolic syndrome disturbances on vascular wall.
We also plan to uncover the role of growth factors in human vascular smooth muscle cells dysfunction in diabetes mellitus and check the potential of natural polyphenolic derivatives (sirtuins activators) to modulate vascular cells energetics and inflammation in experimental diabetes/obesity.
To assess the implications of circulating microparticles, platelets and EPCs in experimental hypertension-hypercholesterolemia.
The new equipment acquired by the CARDIOPRO project will be exploited in the forthcoming research of the Department. Equally, we will benefit of the new equipments of the Cell Culture laboratory, the new facilities of the Experimental Modelling Platform, and the up-dated technology implemented in the other departments of the institute.
Current collaborations
International
- Prof. Juan Antonio Rosado, Department of Physiology (Cell Physiology Research Group), University of Extremadura, Cáceres, Spain
- Prof. Chantal Boulanger, INSERM (French Institute of Health and Medical Research), Cardiovascular Research Center at Lariboisiere, France
- Prof. Frank Dietmar Böhmer, Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Friederich Schiller University, Jena, Germany
National:
- Emergency Hospital, Bucharest, Romania
- “Elias” University Emergency Hospital, Bucharest, Romania
- “Dr. D. Gerota” Hospital, Bucharest, Romania
- University of Bucharest, Faculty of Biology, Romania
- Institute of Diabetes, Nutrition and Metabolic Diseases “Nicolae Paulescu”, Bucharest, Romania
- “Petru Poni” Institute of Macromolecular Chemistry, Iasi, Romania
Participation to-, and grants awarded by competition (1979-2012):
National Institutes of Health, USA (3), European Community (3), and National grants (44).
Awards (1990-2012)
- “Emil Racovita“ Award of the Romanian Academy, 1991 (Doina Popov)
- “Nicolae Simionescu Award of the Romanian Academy, 2008 (Adriana Georgescu)
- “Dr. Constantin Velican” Award of the Romanian Society for Cell Biology, 2001 (Doina Popov); 2010 (Adriana Georgescu)
- Second Prize at the European Life Scientist Organization Meeting, Nice, France, 2002 (Adriana Georgescu)
- “Young Investigator” Award of the Healthy Nutrition Foundation, Bucharest, 2002 (First Prize-Adriana Georgescu, Second Prize-Alina Carale)
- “Agora Diabetologica” Award of the Romanian Society for Diabetes, Nutrition and Metabolic Diseases, Berlin-Chemie, Menarini Group and Eli Lilly 2002 (Alina Carale)
- "European Society on Vascular Biology and Medicine” Award for paper presentation, 4th European Meeting on Vascular Biology and Medicine, Bristol, 2007, U. K. (Adriana Georgescu)
- Scientific Achievements – Original Article Awards of the Ministry for Education and Research (13) (Adriana Georgescu, Nicoleta Alexandru)
- Developing World Scientist Grants of the International Society on Thrombosis and Haemostasis for the presentation at XXII Congress of International Society on Thrombosis and Haemostasis, Boston – USA , 2009 (Adriana Georgescu).
- Award of the 29th Meeting of the Romanian Society for Cell Biology, 2011 (Adriana Georgescu )
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