NEW PUBLICATIONS
* Alina Constantin, Alexandru Filippi, Nicoleta Alexandru, Miruna Nemecz, Adriana Georgescu. Extracellular vesicles from adipose tissue stem cells in diabetes and associated aardiovascular disease; pathobiological impact and therapeutic potential. Int. J. Mol. Sci. 2020, 21(24), 9598; https://doi.org/10.3390/ijms21249598 - IF: 4.556
* Alexandru N.,Constantin A., Nemecz M., Comariţa I.K., Vîlcu A., Procopciuc A., Tanko G. and Georgescu A. Hypertension associated with hyperlipidemia induced different microRNA expression profiles in plasma, platelets, and platelet-derived microvesicles; effects of endothelial progenitor cell therapy. Frontiers in Medicine, 6 (Article 280):1-10, 2020. (IF: 3.113)
* Alexandru† N., Andrei† E., Safciuc F., Dragan E., Balahura A.M., Badila E., Georgescu A. Intravenous administration of allogenic cell-derived microvesicles of healthy origins defends against atherosclerotic cardiovascular disease development by a direct action on endothelial progenitor cells. Cells, 9 (2), 423:1-24, 2020. (†These authors contributed equally to this work). (IF: 5.656)
* Filippi A., Constantin A., Alexandru N., Voicu G., Constantinescu C.A., Rebleanu D., Fenyo M., Simionescu D., Simionescu A., Manduteanu I., Georgescu A. Integrins α4β1 and αVβ3 are reduced in endothelial progenitor cells from diabetic dyslipidemic mice and may represent new targets for therapy in aortic valve disease. Cell Transplantation, Volume 29: 1–8, 2020, DOI: 10.1177/0963689720946277. IF: 3.341
Invited talks at international conferences
* Nemecz M., Georgescu A., Simionescu M. Oleic acid protects human pancreatic beta cells against palmitic acid-induced lipotoxicity; an alternative therapeutic strategy to improve beta-cell survival in diabetes. INTERDIAB 2020 - 6th International Conference on Interdisciplinary Management of Diabetes Mellitus and its Complications. Diabetes Mellitus in Internal Medicine, March 5th-7th, 2020, Bucharest, Romania.
* Alexandru Filippi, Alina Constantin, Nicoleta Alexandru, Cristina Ana Mocanu (Constantinescu), Madalina Fenyo, Dan Simionescu, Agneta Simionescu, Ileana Manduteanu, Adriana Georgescu. Evaluation of the effects of genetically engineered allogeneic endothelial progenitor cell therapy on the structure and function of the aortic valve in diabetes associated with atherosclerosis. Workshop-Theravaldis, November 27 th, 2020, Bucharest, Romania.
The papers (posters) presented at international meetings
* N. Alexandru, A. Constantin, M. Nemecz, I. K. Comarița, A. Vîlcu, A. Procopciuc, G. Tanko, A. Georgescu. Effects of endothelial progenitor cell therapy on microRNA expression profiles in plasma, platelets and platelet-derived microvesicles in atherosclerosis. Poster 401 /#1275 at the ‘88th European Atherosclerosis Society Virtual Congress’ (EAS 2020), October 4th -7th, 2020, Geneva, Switzerland, Abstract in Atherosclerosis,Volume 315, Page e136, Publication date: 2020/12/1, DOI: https://doi.org/10.1016/j.atherosclerosis.2020.10.420.
* I.K. Comarița, A. Vîlcu, A. Procopciuc, F. Safciuc, A. Constantin, M. Nemecz, G. Tanko, N. Alexandru,A. Georgescu. The hypertensive-hyperlipidemic hamster, an experimental animal model of atherosclerosis to investigate the vascular dysfunction and cardiac hypertrophy. Poster 347 / #1345 at the ‘88th European Atherosclerosis Society Virtual Congress’ (EAS 2020), October 4th-7th, 2020, Geneva, Switzerland. Abstract in Atherosclerosis,Volume 315, Page e120, Publication date:2020/12/1, DOI:https://doi.org/10.1016/j.atherosclerosis.2020.10.367
* Ioana Karla Comarita, Alexandra Vilcu, Anastasia Procopciuc, Nicoleta Alexandru, Alina Constantin, Florentina Safciuc, Alexandru Filippi, Miruna Nemecz, Gabriela Tanko, Adriana Georgescu. Exploration of Vascular Dysfunction in an Animal Model of Atherosclerotic Cardiovascular Disease. International Online Conference of Biophysics, 14-16 June 2020, Brașov, România, Book of Abstracts, p. 99.
Awards
National Prizes
‘Scientific Achievements – Original Article’ Award offered by Ministry for Education and Research and Uefiscdi, Subprogram 1.1 - Human Resources - Awarding research results - Articles, Competition 2020, Evaluation results List 1_partial 2- Award applications submitted for articles published in 2019_09.11.2020, – November 2020, for the paper ‘Hypertension associated with hyperlipidemia induced different microRNA expression profiles in plasma, platelets, and platelet-derived microvesicles; effects of endothelial progenitor cell therapy’ in ‘Frontiers in Medicine’, 6 (Article 280):1-10, 2019. (N. Alexandru, A. Constantin, M. Nemecz, I.K. Comariţa, A. Vîlcu, A. Procopciuc, G. Tanko and A. Georgescu).
‘Scientific Achievements – Original Article’ Award offered by Ministry for Education and Research and Uefiscdi, Subprogram 1.1 - Human Resources - Awarding research results - Articles, Competition 2020, Evaluation results List 1_partial 3- Award applications submitted for articles published in 2020_19.11.2020, – November 2020, for the paper ‘Intravenous administration of allogenic cell-derived microvesicles of healthy origins defends against atherosclerotic cardiovascular disease development by a direct action on endothelial progenitor cells’ in ‘Cells’, 9 (2),423:1-24, 2020. (N. Alexandru†, E. Andrei†, F. Safciuc, E. Dragan, A.M. Balahura, E. Badila, A. Georgescu).
‘Scientific Achievements – Original Article’ Award offered by Ministry for Education and Research and Uefiscdi, Subprogram 1.1 - Human Resources - Awarding research results - Articles, Competition 2020, Evaluation results List 3- Award applications submitted for articles published in 2020_27.11.2020, – November 2020 for the paper ‘Integrins α4β1 and αVβ3 are reduced in endothelial progenitor cells from diabetic dyslipidemic mice and may represent new targets for therapy in aortic valve disease’ in Cell Transplantation, Volume 29:1–8, 2020. (Filippi A., Constantin A., Alexandru N., Voicu G., Constantinescu C.A., Rebleanu D., Fenyo M., Simionescu D., Simionescu A., Manduteanu I., Georgescu).
Patents:
Process for obtaining genetically modified endothelial progenitor cells. Patent Application, OSIM No. A/00284 of 25.05.2020. Authors: Alexandru Filippi, Loredana Antonescu, Alina Constantin, Cristina Constantinescu, Nicoleta Alexandru, Adriana Georgescu
Process for obtaining modified extracellular vesicles. Patent Application, OSIM No. A/00017 of 20.01.2021. Authors: Alexandru Filippi, Nicoleta Alexandru-Moise, Alina Constantin, Karla Comarită, Alexandra Vîlcu, Anastasia Procopciuc, Adriana Georgescu
