The strive continues; science is infinite, has no limits, no frontiers, no borders. Just like Brancusi’s "Endless Column", science is a permanent, endless exploration to uncover nature’s secrets, including our own. This is the adventure we have and are embarked on. One of us had to leave earlier.
Cardiovascular disease represents more than 55% of the world-wide death rate. The World Health Organisation predicted that by 2020 cardiovascular disease will be the leading global cause of total disease burden. In the case of atherosclerosis, the first signs appear in young individuals but in time, as a function of numerous risk factors and genetic determinants, they evolve towards advanced atherosclerotic plaques. These plaques finally impede partially or totally the blood flow through a territory of the heart or brain, leading to myocardial infarction or stroke. The uncovering of critical events and the pathobiochemistry of vascular diseases will provide the tools and the markers for clinical screening, early diagnosis and efficient treatment of these maladies.
The concept and the term "Transcytosis" and "Receptor Mediated Transcytosis". In 1979, Nicolae Simionescu published a paper in which his new and inspired term "transcytosis" was for the first time introduced in the scientific literature.