Networking & Grants
COFEX

FP5 Grant No. ICA1-CT-2000-70020. 2001-2004  Function and dysfunction of blood vessels: transcytosis in normal/pathological states, alterations in atherosclerosis and diabetes; their therapeutic control.

Center of Excellence of the European Community “Blood Vessels”
2001 - 2003

Major goals of the Centre of Excellence

  • Biomedical research
  • Collaboration
  • International scientific exchanges
  • Open Institution for higher education
  • PhD;  Master program - specialization
  • Disseminate information
  • Links with clinics and European pharmaceutical companies

 

Statement of purpose

Understanding, prevention, early diagnosis and better therapeutic control of cardiovascular diseases

Initial and late pathobiochemical alterations of heart and blood vessels: atherosclerosis, diabetes,  obesity, ageing.

 

Our Team

 

Research goals and major steps envisaged

Agenda Centre of Excellence

  • Biomedical research connect to cardiovascular diseases - the main causes of death in developed countries, diabetes, ageing.
  • Enhancing exchanges and linkage with EU scientists or other centers of excellence.
  • Inviting EU scientists to work in our Centre, on common projects.
  • Organize a workshop and minisymposia to increase connections and collaborations with other EU Labs
  • Develop a Molecular Biology Laboratory and new techniques.
  • Extension of the relationships with pharmaceutical firms such as Merck, Novartis, Sanofi, etc
  • Participation in FP6 projects

WORK-PACKAGES OF CENTRE OF EXCELLENCE

WP 1

Transcytosis of molecules through vascular wall in normal and pathological conditions

Achievements:

Exchanges:   3 visitors from EU
                    3 researchers from the centre

Countries:   Switzerland, Germany, England, France, Austria

Meetings:   one paper ESF Meeting, Portugal
                 one invited speaker EURESCO Conference, Spain
                11 participations to international symposia;
                 2 participations to international symposia;

Advanced Studies School: “From Cell and Molecular Biology to the   Medicine of the 21st Century” – ICBP: 2001-2002

Publications:   8 articles published and 3 in preparation

National Research Program: 8 grants

Awards:   4 researchers from the centre

FP6:   Participation to Marie Curie Action

 

WP 2

Cellular and molecular events occurring during atherogenesis

Achievements

Exchanges:   4 visitors from EU
                   1 researchers from the centre

Countries:   Germany, Belgium, France

Meetings:   - Workshop : “Cardiovascular Dysfunction in Hyperlipidemia and Diabetes”
                 - Meeting of the COST action B17 - Working Group 5 Cardiovascular Dysfunction
                                  150 participants, 31 platform presentations,
                                  30 posters,   Panel Discussion for FP 6
                 - one invited speaker EURESCO Conference, Spain,
                 - 19 participations to international symposia;
                 - 20 participations to national symposia;

Publications:  12 articles and 3 in preparation

National Research Program:  7 grants

FP6:  Participation to 2 projects

 

WP 3

Alterations of blood vessels reactivity in experimental hyperlipemia/diabetes

Achievements

Exchanges:   2 visitors from EU
                   3 researchers from the centre

Countries:   England, Scotland, Germany, Hungary

Meetings:   - 8 participations to international symposia;
                 - 16 participations to national symposia;

Publications:   7 articles; 2 monograph chapters, 2 manuscripts in  preparation

National Research Program: 6 grants

FP6:  Participation to 1 project

Awards:   3 awards

 

WP 4

Cellular and molecular effect of drugs used in cardiovascular diseases

Achievements

Exchanges:   1 visitor from Germany

Meetings:   - 5 participations to international symposia;
                 - 9 participations to national symposia;

Publications:   7 articles

National Research Program: 8 grants

Awards:  3 awards

 

Visit of Mrs. Jitka Vennekens-Capkova  to the Centres of Excellence of Romania

 

New findings and concepts

Concepts

•  Transcytosis and its mechanisms.
•  Identifiction of new endothelial receptors (albumin binding proteins, histamine receptors, FcRn and  a new Fc receptor on EC).
•  Pathobiochemical events occurring at the inception of atherosclerosis (prelesional stage)
• Alteration induced by hyperglycemia on Lp

Original Animal models

•  Hyperlipemic hamster
•  Hyperlipemic-hyperglicaemic hamster 

New Cell lines

• Placental EC, human SMC, transfected EC etc.  
• In vitro model for drug testing
 
 

Future plans

  • Maintaining the competitive research
  • Extension of the collaborations
  • More applications in FP6
  • Improvement of the technological transfer
  • Continuing the formation of new specialists in cell biology and pathology
  • Increase the visibility of the Centre
  • Maintain the status of Centre of Excellence at the European level

 

Memorandum I

Contribution of the CoE label to the development of the Institute 

  • Since in previous 20 years of the activity of our Institute we collaborated mainly with laboratories from USA, the label of CoE increased the exchanges and enlarged collaboration with European laboratories.
  • The visits of scientists were of great benefit to disseminate our results, to improve the technology and to expand our research by starting new projects of mutual interest.
  • The CoE label enhanced the Institution reputation within the national and international community. As a result, we were successful in getting more national grants and we received proposals and invitations and participated to projects in FP5 and FP6.
  • The centre became an education site organizing annually an Advanced Study School for Ph.D. students and postdoctoral fellows (with Romanian and foreign invited speakers), minisymposia and an international workshop held jointly with the meeting of the COST- Action B17, WG 5 to which 150 prominent scientists (from 11 European countries and Romania) participated. The meeting included a panel discussion regarding the FP6, ERA, how to increase the visibility of the Centre, cooperation and to improve the capacity to acquire and manage research projects.
  • We started to develop a new activity, namely conducting PhD thesis in “co-tutele” with partners from Europe and USA.
  • Ten prizes and awards honored our researchers (many Ph.D. students).
  • Recognition of the activity of our Institute with the label of CoE was a signal for the researcher from our scientific community that high-quality science is acknowledged and increased the importance of science for the general public.
  • We were pleased that all the objectives of the Centre have been reached and the results are superior to those previously planned. 

 

Memorandum II

Plans and Intention of the Activity of the Centre in the near future

  • To maintain the status of Centre of Excellence and to increase the visibility of out Institute by obtaining solid and reliable data and publishing more papers on biomedical research. We will use the cell and molecular biology as a tool to understand a defeat global risk diseases such as atherosclerosis, diabetes and obesity. 
  • To continue our international collaborations and exchanges between scientists.  
  • To expand our scientific agenda and increase research quality and cooperation.
  • To organize international minisimposia and workshop in our Institute so that scientists from the entire country will be exposed to the results obtained in other laboratories from Europe.
  • To participate to the projects of the FP6
  • To continue to be an education site by organizing the annual AdvancedStudySchool and have all the laboratories open for training Ph.D.students, postdocs, and medical residents.
  • It is our opinion that the achievements obtained so far will benefit and greatly increase if the Centre of Excellence label will be allowed to be used after the end of the project. The label “Centre of Excellence” attracted more young scientists in the Institute and to a certain extent slowed down the brain drain. We believe that this will be in the interest of all Centre of Excellence and of the development of the European Research Area.