Publicații

Lucrări indexate ISI/PubMed, articole în alte baze de date și capitole de carte.

A. Lucrări indexate în PubMed

43 LUCRĂRI

1. Helping Apo2L/TRAIL in the Battle: Synergistic Therapeutic Approaches for Cancer Therapies
   Fuior EV, Dumitrescu M, Multescu MG, Daraban BS, Ghinea M, Mirancea O, Petrescu GED, Brehar FM, Vacaru AM, Ionita R, Bivol VG, Tudorache IF, Popa A, Fenyo IM, Zvintzou E, Gafencu AV.
   Int J Mol Sci. 2026 Aug 7;27(16):7068. doi: 10.3390/ijms27167068.

   Full text

2. Unmet Cardiovascular Risk Beyond LDL-C: A Systems-Level Approach to Emerging Mechanisms and Novel Therapeutics
   Kypreos KE, Gafencu AV, Andreopoulou O, Zvintzou E, Marinos K, Mparnia V, Alemi M, Daraban BS, Multescu MG, Ghinea M, Mirancea O.
   Pharmaceuticals. 19(7):1071. Q1, IF 5.7.

   Full text

3. Context-Dependent Effects of Apolipoprotein A2 on Lipid Metabolism and Atherogenesis
   Zvintzou E, Fenyo IM, Ionita R, Kakafoni G, Dumitrescu M, Alemi M, Daraban BS, Marinos K, Gafencu AV, Kypreos KE.
   FASEB J. 2026 Jun 30;40(12):e72032. doi: 10.1096/fj.202600765R.

   PMID 42268249

4. Amino acid residues L261, W264, F265, L268, and V269 of apolipoprotein E4 critically regulate adipose tissue metabolism
   Zvintzou E, Giannopoulou PC, Giannatou K, Ionita R, Alemi M, Kakafoni G, Mparnia V, Dumitrescu M, Fenyo IM, Gafencu AV, Kypreos KE.
   J Lipid Res. 2026 Jan;67(1):100958. doi: 10.1016/j.jlr.2025.100958. Epub 2025 Dec 5.

   PMID 41354325

5. Hypertriglyceridemia impairs HDL functionality, promotes macrophage metabolic activation and exacerbates antigen-induced rheumatoid arthritis in mice which can be reversed by fenofibrate treatment
   Axiotis I, Kakale A, Lazaridou D, Dedemadi AG, Chroni A, Multescu M, Gafencu AV, Tzardi M, Kardassis D.
   Biochim Biophys Acta Mol Cell Biol Lipids. 2025 Sep 8;1870(8):159686.

   PubMed

6. Unravelling molecular mechanisms in atherosclerosis using cellular models and omics technologies
   Kardassis D, Vindis C, Stancu CS, Toma L, Gafencu AV, Georgescu A, Alexandru-Moise N, Molica F, Kwak BR, Burlacu A, Hall IF, Butoi E, Magni P, Wu J, Novella S, Gamon LF, Davies MJ, Caporali A, de la Cuesta F, Mitić T.
   Vascul Pharmacol. 2025 Mar;158:107452. doi: 10.1016/j.vph.2024.107452. Epub 2024 Dec 10.

   PMID 39667548

7. Proteometabolomics of initial and recurrent glioblastoma highlights an increased immune cell signature with altered lipid metabolism
   Cosenza-Contreras M, Schäfer A, Sing J, Cook L, Stillger MN, Chen CY, Hidalgo JV, Pinter N, Meyer L, Werner T, Bug D, Haberl Z, Kübeck O, Zhao K, Stei S, Gafencu AV, Ionita R, Brehar FM, Ferrer-Lozano J, Ribas G, Cerdá-Alberich L, Martí-Bonmatí L, Nimsky C, Van Straaten A, Biniossek ML, Föll M, Cabezas-Wallscheid N, Büscher J, Röst H, Arnoux A, Bartsch JW, Schilling O.
   Neuro Oncol. 2023 Oct 26:noad208. doi: 10.1093/neuonc/noad208.

   PMID 37882631

8. Peroxisome Proliferator-Activated Receptor α in Lipoprotein Metabolism and Atherosclerotic Cardiovascular Disease
   Fuior EV, Zvintzou E, Filippatos T, Giannatou K, Mparnia V, Simionescu M, Gafencu AV, Kypreos KE.
   Biomedicines. 2023 Oct 3;11(10):2696. doi: 10.3390/biomedicines11102696.

   DOI

9. Synthetic lipoproteins based on apolipoprotein E coupled to fullerenol have anti-atherosclerotic properties
   Tudorache IF, Bivol VG, Dumitrescu M, Fenyo IM, Simionescu M, Gafencu AV.
   Pharmacol Rep. 2022 Aug;74(4):684-695. doi: 10.1007/s43440-022-00379-8. Epub 2022 Jul 5.

   PMID 35790693

10. Apolipoprotein A-II, a Player in Multiple Processes and Diseases
    Florea G, Tudorache IF, Fuior EV, Ionita R, Dumitrescu M, Fenyo IM, Bivol VG, Gafencu AV.
    Biomedicines. 2022 Jul 2;10(7):1578. doi: 10.3390/biomedicines10071578.

    PMID 35884883

11. Treatment with Mesenchymal Stromal Cells Overexpressing Fas-Ligand Ameliorates Acute Graft-versus-Host Disease in Mice
    Vacaru AM, Mazilu AM, Dumitrescu M, Fenyo IM, Gafencu AV, Vacaru AM.
    Int J Mol Sci. 2022 Jan 4;23(1):534. doi: 10.3390/ijms23010534.

    PMID 35008964

12. An Efficient Method for Adenovirus Production
    Dumitrescu M, Trusca VG, Fenyo IM, Gafencu AV.
    J Vis Exp. 2021 Jun 10;(172). doi: 10.3791/61691.

    PMID 34180881

13. K2 Transfection System Boosts the Adenoviral Transduction of Murine Mesenchymal Stromal Cells
    Dumitrescu M, Vacaru AM, Trusca VG, Fenyo IM, Ionita R, Gafencu AV.
    Int J Mol Sci. 2021 Jan 9;22(2):598. doi: 10.3390/ijms22020598.

    PMID 33435318

14. Enhanced Suppression of Immune Cells In Vitro by MSC Overexpressing FasL
    Vacaru AM, Dumitrescu M, Vacaru AM, Fenyo IM, Ionita R, Gafencu AV, Simionescu M.
    Int J Mol Sci. 2020 Dec 31;22(1):348. doi: 10.3390/ijms22010348.

    PMID 33396269

15. Adenovirus-Mediated FasL Minigene Transfer Endows Transduced Cells with Killer Potential
    Dumitrescu M, Trusca VG, Savu L, Stancu IG, Ratiu AC, Simionescu M, Gafencu AV.
    Int J Mol Sci. 2020 Aug 20;21(17):6011. doi: 10.3390/ijms21176011.

    PMID 32825521

16. Simple and dual cross-linked chitosan millicapsules as a particulate support for cell culture
    Fundueanu G, Constantin M, Bucatariu S, Nicolescu A, Ascenzi P, Moise LG, Tudor L, Trusca VG, Gafencu AV, Ficai D, Ficai A, Andronescu E.
    Int J Biol Macromol. 2020 Jan 15;143:200-212. doi: 10.1016/j.ijbiomac.2019.12.045. Epub 2019 Dec 6.

    PMID 31816371

17. The Mechanism of Bisphenol A Atherogenicity Involves Apolipoprotein A-I Downregulation through NF-κB Activation
    Trusca VG, Dumitrescu M, Fenyo IM, Tudorache IF, Simionescu M, Gafencu AV.
    Int J Mol Sci. 2019 Dec 12;20(24):6281. doi: 10.3390/ijms20246281.

    PMID 31842455

18. Apolipoprotein C1: Its Pleiotropic Effects in Lipid Metabolism and Beyond
    Fuior EV, Gafencu AV.
    Int J Mol Sci. 2019 Nov 26;20(23):5939. doi: 10.3390/ijms20235939.

    PMID 31779116

19. The Opposite Effect of c-Jun Transcription Factor on Apolipoprotein E Gene Regulation in Hepatocytes and Macrophages
    Trusca VG, Fuior EV, Kardassis D, Simionescu M, Gafencu AV.
    Int J Mol Sci. 2019 Mar 23;20(6):1471. doi: 10.3390/ijms20061471.

    PMID 30909560

20. Apolipoprotein E — A Multifunctional Protein with Implications in Various Pathologies as a Result of Its Structural Features
    Tudorache IF, Trusca VG, Gafencu AV.
    Comput Struct Biotechnol J. 2017 Jun 6;15:359-365. doi: 10.1016/j.csbj.2017.05.003.

    PMID 28660014

21. Preferential Association of Lissencephaly-1 Gene Expression with CD133+ Glioblastoma Cells
    Brehar FM, Gafencu AV, Trusca VG, Fuior EV, Arsene D, Amaireh M, Giovani A, Gorgan MR.
    J Cancer. 2017 May 11;8(7):1284-1291. doi: 10.7150/jca.17635.

    PMID 28607604

22. Differential action of glucocorticoids on apolipoprotein E gene expression in macrophages and hepatocytes
    Trusca VG, Fuior EV, Fenyo IM, Kardassis D, Simionescu M, Gafencu AV.
    PLoS One. 2017 Mar 29;12(3):e0174078. doi: 10.1371/journal.pone.0174078.

    PMID 28355284

23. High levels of homocysteine downregulate apolipoprotein E expression via nuclear factor kappa B
    Trusca VG, Mihai AD, Fuior EV, Fenyo IM, Gafencu AV.
    World J Biol Chem. 2016 Feb 26;7(1):178-87. doi: 10.4331/wjbc.v7.i1.178.

    PMID 26981206

24. Krüppel-like factor 4 synergizes with CREB to increase the activity of apolipoprotein E gene promoter in macrophages
    Stavri S, Simionescu M, Kardassis D, Gafencu AV.
    Biochem Biophys Res Commun. 2015 Dec 4-11;468(1-2):66-72. doi: 10.1016/j.bbrc.2015.10.163. Epub 2015 Nov 4.

    PMID 26546821

25. Thyroid hormones upregulate apolipoprotein E gene expression in astrocytes
    Roman C, Fuior EV, Trusca VG, Kardassis D, Simionescu M, Gafencu AV.
    Biochem Biophys Res Commun. 2015 Dec 4-11;468(1-2):190-5. doi: 10.1016/j.bbrc.2015.10.132. Epub 2015 Oct 29.

    PMID 26519880

26. Metformin reduces the endotoxin-induced down-regulation of apolipoprotein E gene expression in macrophages
    Stavri S, Trusca VG, Simionescu M, Gafencu AV.
    Biochem Biophys Res Commun. 2015 May 29;461(2):435-40. doi: 10.1016/j.bbrc.2015.04.057. Epub 2015 Apr 18.

    PMID 25899745

27. Beyond Lipoprotein Receptors: Learning from Receptor Knockouts Mouse Models about New Targets for Reduction of the Atherosclerotic Plaque
    Trusca VG, Fuior EV, Gafencu AV.
    Curr Mol Med. 2015;15(10):905-31. doi: 10.2174/1566524016666151123110310.

    PMID 26592248

28. Regulation of HDL genes: transcriptional, posttranscriptional, and posttranslational
    Kardassis D, Gafencu A, Zannis VI, Davalos A.
    Handb Exp Pharmacol. 2015;224:113-79. doi: 10.1007/978-3-319-09665-0_3.

    PMID 25522987

29. The involvement of the monocytes/macrophages in chronic inflammation associated with atherosclerosis
    Fenyo IM, Gafencu AV.
    Immunobiology. 2013 Nov;218(11):1376-84. doi: 10.1016/j.imbio.2013.06.005. Epub 2013 Jun 19.

    PMID 23886694

30. STAT1 interacts with RXRα to upregulate ApoCII gene expression in macrophages
    Trusca VG, Florea IC, Kardassis D, Gafencu AV.
    PLoS One. 2012;7(7):e40463. doi: 10.1371/journal.pone.0040463. Epub 2012 Jul 12.

    PMID 22808166

31. Macrophage-specific up-regulation of apolipoprotein E gene expression by STAT1 is achieved via long range genomic interactions
    Trusca VG, Fuior EV, Florea IC, Kardassis D, Simionescu M, Gafencu AV.
    J Biol Chem. 2011 Apr 22;286(16):13891-904. doi: 10.1074/jbc.M110.179572. Epub 2011 Mar 3.

    PMID 21372127

32. AP-1-dependent transcriptional regulation of NADPH oxidase in human aortic smooth muscle cells: role of p22phox subunit
    Manea A, Manea SA, Gafencu AV, Raicu M, Simionescu M.
    Arterioscler Thromb Vasc Biol. 2008 May;28(5):878-85. doi: 10.1161/ATVBAHA.108.163592. Epub 2008 Feb 28.

    PMID 18309110

33. Regulation of NADPH oxidase subunit p22(phox) by NF-kB in human aortic smooth muscle cells
    Manea A, Manea SA, Gafencu AV, Raicu M.
    Arch Physiol Biochem. 2007 Oct-Dec;113(4-5):163-72. doi: 10.1080/13813450701531235.

    PMID 18158642

34. Inflammatory signaling pathways regulating ApoE gene expression in macrophages
    Gafencu AV, Robciuc MR, Fuior E, Zannis VI, Kardassis D, Simionescu M.
    J Biol Chem. 2007 Jul 27;282(30):21776-85. doi: 10.1074/jbc.M611422200. Epub 2007 Jun 6.

    PMID 17553793

35. Proliferation, differentiation and characterization of osteoblasts from human BM mesenchymal cells
    Titorencu I, Jinga V, Constantinescu E, Gafencu A, Ciohodaru C, Manolescu I, Zaharia C, Simionescu M.
    Cytotherapy. 2007;9(7):682-96. doi: 10.1080/14653240701561329.

    PMID 17917883

36. Relationship of eNOS gene variants to diseases that have in common an endothelial cell dysfunction
    Heltianu C, Costache G, Gafencu A, Diaconu M, Bodeanu M, Cristea C, Azibi K, Poenaru L, Simionescu M.
    J Cell Mol Med. 2005 Jan-Mar;9(1):135-42. doi: 10.1111/j.1582-4934.2005.tb00343.x.

    PMID 15784171

37. Investigation of IgG receptors expressed on the surface of human placental endothelial cells
    Gafencu A, Heltianu C, Burlacu A, Hunziker W, Simionescu M.
    Placenta. 2003 Jul;24(6):664-76. doi: 10.1016/s0143-4004(03)00041-9.

    PMID 12828925

38. Transcytosis of plasma macromolecules in endothelial cells: a cell biological survey
    Simionescu M, Gafencu A, Antohe F.
    Microsc Res Tech. 2002 Jun 1;57(5):269-88. doi: 10.1002/jemt.10086.

    PMID 12112439

39. Severity of oxidative stress generates different mechanisms of endothelial cell death
    Burlacu A, Jinga V, Gafencu AV, Simionescu M.
    Cell Tissue Res. 2001 Dec;306(3):409-16. doi: 10.1007/s004410100424. Epub 2001 Oct 23.

    PMID 11735041

40. Expression of functionally active FcRn and the differentiated bidirectional transport of IgG in human placental endothelial cells
    Antohe F, Rădulescu L, Gafencu A, Gheţie V, Simionescu M.
    Hum Immunol. 2001 Feb;62(2):93-105. doi: 10.1016/s0198-8859(00)00244-5.

    PMID 11182218

41. Establishment of a pure vascular endothelial cell line from human placenta
    Jinga VV, Gafencu A, Antohe F, Constantinescu E, Heltianu C, Raicu M, Manolescu I, Hunziker W, Simionescu M.
    Placenta. 2000 May;21(4):325-36. doi: 10.1053/plac.1999.0492.

    PMID 10833367

42. Protein and fatty acid composition of caveolae from apical plasmalemma of aortic endothelial cells
    Gafencu A, Stanescu M, Toderici AM, Heltianu C, Simionescu M.
    Cell Tissue Res. 1998 Jul;293(1):101-10. doi: 10.1007/s004410051102.

    PMID 9634602

43. Expression of transferrin receptors in endothelial cells transfected by electroporation
    Heltianu C, Serban G, Alexandru V, Gafencu A, Simionescu N, Simionescu M.
    Eur J Cell Biol. 1997 Jan;72(1):79-89.

    PMID 9013729

B. Publicații indexate în alte baze de date

8 LUCRĂRI

1. Transfection of type I receptor for immunoglobulin G in bovine aortic endothelial cells
   Neagoe C, Gafencu A, Heltianu C.
   Current Protocols in Cell Biology. 1998;3:378-383.
2. Immortalization of endothelial cells
   Gafencu A, Heltianu C, Burlacu A, Hunziker W, Simionescu M.
   Proceedings of the Romanian Academy, Series B. 2001;2:117-121.
3. Hyperlipemic serum stimulates the binding and the endocytosis of IgG by the endothelial aortic cells
   Gafencu A, Postea O, Heltianu C, Simionescu M.
   Current Problems and Techniques in Cellular and Molecular Biology. 2001:79-83.
4. Albumin binding sites in human placental endothelial cells
   Gafencu A, Dutca M, Heltianu C.
   Analele SNBC. 2003:64-68.
5. Expression of apoE3-HRP chimeric molecule in HEK293 cells
   Florea IC, Trusca VG, Fenyo IM, Gafencu AV.
   Annals of the Romanian Society for Cell Biology. 2009;XIV(2):21-27.
6. The expression of translin is regulated by inflammatory stimuli in monocytes and macrophages
   Fuior EV, Trusca VG, Fenyo IM, Gafencu AV.
   Annals of R.S.C.B. 2015;XIX(2):33-40.
7. Enzymatic targets in atherosclerosis
   Fuior EV, Trusca VG, Roman C, Gafencu AV.
   J Mol Genet Med. 9:176.
8. High levels of homocysteine downregulate apolipoprotein E expression via NF-kB
   Trusca VG, Mihai AD, Fuior EV, Fenyo IM, Gafencu AV.
   World Journal of Biological Chemistry. 2016;7(1):178-87. doi: 10.4331/wjbc.v7.i1.178.

C. Capitole de carte

3 CAPITOLE

1. Molecular targets for atherosclerosis treatment
   Fenyo IM, Gafencu AV.
   În: From Vascular Cell Biology to Cardiovascular Medicine, 2011. ISBN 978-81-7895-503-2.
2. Organotypic brain slice model in glioblastoma research
   Brehar FM, Gafencu A, Gorgan MR.
   În: Experimental Models in Glioblastoma Research, Nova Science Publishers, 2015:73-83. ISBN 978-1-63482-535-1; 978-1-63321-924-3.
3. Signaling Pathways Regulating Gene Expression in Atherosclerosis
   Gafencu AV, Fenyo IM, Fuior EV, Dumitrescu M, Mirancea O, Multescu M, Tudorache IF, Basílio J, Schmid JA, Kardassis D.
   În curs de apariție, 2025.