Research
Achievements & Original concepts/ Realizari & Concepte originale

ORIGINAL CONCEPTS AND SELECTED FINDINGS/ CONCEPTE ORIGINALE SI SELECTIE A DESCOPERIRILOR

  • Transcytosis of molecules and its mechanisms: fluid phase, adsorptive and receptor mediated;
  • Histamine receptors are expressed preferentially on venular endothelial cells (EC);
  • Hyperglycemia induced - increased atherogenicity of lipoproteins contribute to accelerated atherosclerosis in diabetes;
  • Albumin binding proteins are expressed by endothelial cells and cardiomyocytes;
  • The initial event in atherogenesis is the accumulation of modified lipoproteins within the subendothelial space of the aorta, cardiac valves, coronary arteries of humans and experimental animals;
  • Endothelial cell response to normal and abnormal stimuli;
  • Inhibition of atheroma formation is potentiated by the association of ACE26 inhibitors with calcium channel blockers;
  • Identification of FcRn in human placental endothelial cells;
  • Detection of new Fc-receptor on placental endothelial cell;
  • Detection of new antigens in activated EC by high resolution 2-D gel electrophoresis;
  • Polymorphism of candidate gene (eNOS, ACE) is associated with endothelial dysfunction in atherosclerosis and diabetes;
  • In experimental hyperlipemia-hyperglycemia administration of L-arginine improves the microangiopathic changes of coronaries and enhances vasodilation of resistance arteries;
  • High uptake of folic acid by activated macrophages in experimental hyperlipidemia;
  • Circulating microparticles contribute to human peripheral venular dysfunction;
  • Calcium channel blockers (felodipine, amlodipine) and ACE inhibitor (enalapril maleat) regulate NADPH oxidase in pericytes;
  • Nifedipine has deleterious effects on calcium homeostasis and aggravates atheroma formation;
  • Clotrimazole has comparable properties with calcium antagonists;
  • Enoxaparin restores the vascular reactivity of resistance arteries in ageing and diabetes;
  • Enoxaparin reduces monocyte adhesion to TNF-, LPS-, or high glucose-activated EC;
  • Superoxide dismutase entrapped-liposomes restore the impaired endothelium-dependent relaxation of resistance arteries in experimental diabetes;
  • VCAM-1 is an appropriate target for specific delivery of drugs to activated EC by immunoliposomes;
  • Aspirin corrects the high glucose-induced changes in intracellular calcium homeostasis and NO production in human EC;
  • Simvastatin inhibits transcytosis of LDL in hyperlipemia reducing plaque progression;
  • Simvastatin and Amlodipin increase the sera antioxidant potential in patients with stable angina;
  • Atorvastatin downregulates NADPH oxidase activity, and decreases NOX1 and p22phox gene expression in human aortic smooth muscle cells exposed to glycated LDL;
  • Enoxaparin reduces endothelial cell activation;
  • PPARα activators (fenofibrate and clofibrate) inhibit MCP-1 and fractalkine expression induced by high glucose in human smooth muscle cells;
  • PPAR agonists decrease plaque vulnerability through modulation of MMP-2 activity;
  • Anti-oxidant potential of felodipine is higher that that of amlodipine;
  • Nebivolol has a reversible vasodilator effect on renal arteries.

ORIGINAL ANIMAL MODELS

The hyperlipemic hamster
The hyperglycemic / hyperlipemic hamster
The insulin-resistant hamster
L-NAME-induced hypertensive hamster
Hypertensive/hyperlipemic hamster

NEW CELL LINES

Existent in the Cell Culture Core Facility

ADVANCED BIOMEDICAL TRAINING

  • Ph.D. program in cellular and molecular biology
  • Postdoctoral training of scientists from Romania and abroad
  • National and International Congresses of the Romanian Society for Cell Biology
  • Annual Advanced Study School "From Cell and Molecular Biology to the Medicine of 21st Century", under auspices of the Romanian Academy.

CONCEPTE ORIGINALE SI SELECTIE A DESCOPERIRILOR

  • Transcitoza moleculelor si mecanismele ei: faza fluida, adsorbtiva, mediata de receptor;
  • Receptorii la histamina sunt exprimati preferential pe celulele endoteliale venulare (EC);
  • Aterogenicitatea crescuta a lipoproteinelor, indusa de hiperglicemie, contribuie la accelerarea aterosclerozei in diabet
  • Proteinele de legare a albuminei sunt exprimate de celulele endoteliale si cardiomiocite;
  • Evenimentul initial in aterogeneza este acumularea de lipoproteine modificate in spatiul subendotelial al aortei, valvelor cardiace, arterelor coronare ale omului si animalelor de experienta;
  • Raspunsul celulei endoteliale la stimuli normali si anormali;
  • Inhibarea formarii ateromului este potentata de asocierea inhibitorilor ACE26 cu blocantii de canale de calciu;
  • Identificarea FcRn in celulele endoteliale placentare umane;
  • Detectarea de noi receptori Fc pe celulele endoteliale placentare;
  • Detectarea de noi antigeni in CE activate prin electroforeza bidimensionala in gel;
  • Polimorfismul genelor candidate (eNOS, ACE) este este asociat cu disfunctia endoteliala in ateroscleroza si diabet;
  • In hiperlipemia-hiperglicemia experimentala administrarea de L-arginina imbunatateste modificarile microangiopatice ale coronarelor si creste vasodilatatia arterelor de rezistenta;
  • Preluarea crescuta de acid folic de catre macrofagele activate in hiperlipidemia experimentala;
  • Particulele microcirculante contribuie la disfunctia venulara periferica umana;
  • Blocantii de canale de calciu (felodipina, amlodipine) si inhibitorii ACE (enalapril maleat) regleaza NADPH oxidaza in pericite;
  • Nifedipina are efecte deletorii asupra homeostaziei calciului si agraveaza formarea ateromului;
  • Clotrimazolul are proprietati comparabile cu antagonistii de calciu;
  • Enoxaparina reface reactivitatea vasculara a arterelor de rezistenta in imbatranire si diabet;
  • Enoxaparina reduce aderarea monocitelor la endoteliul activat de TNF, LPSsau glucoza;
  • Superoxid dismutaza trapata in liposomi restabileste relaxarea dependenta de endoteliu a arterelor de rezistenta in diabetul experimental;
  • VCAM-1 este o tinta potrivita pentru furnizarea de medicamente prin intermediul liposomilor catre endoteliu activat;
  • Aspirina corecteaza modificarile induse de glucoza in homeostazia calciului intracellular si productia de NO in endoteliul uman;
  • Simvastatin inhiba transcitoza LDL in hiperlipemie, reducand progresia placii;
  • Simvastatin si Amlodipin cresc potentialul antioxidant seric la pacientii cu angina stabila;
  • Atorvastatin scade activitatea NADPH oxidazeisi descreste expresia genica a NOX1 si p22phox in celulele musculare netede de arc aortic expuse la LDL glicat;
  • Enoxaparina reduce activarea celulei endoteliale;
  • Activatorii de PPARα (fenofibrat si clofibrat) inhiba expresia MCP-1 si fractalkinei indusa de glucoza ridicata in celulele musculare netede umane;
  • Agonistii PPAR descresc vulnerabilitatea placii prin modularea activitatii MMP-2;
  • Potentialul antioxidant al felodipinei este mai mare decat cel al amlodipinei;
  • Nebivolol are un efect vasodilatator reversibil pe arterele renale.

 

MODELE ANIMALE ORIGINALE

Hamsterul hiperlipemic

Hamsterul hiperglicemic/ hiperlipemic

Hamsterul rezistent la insulina
Hamsterul cu hipertensiune indusa de L-NAME
Hamsterul hipertensiv/ hiperlipemic

NOI LINII CELULARE

Existente in Laboratorul central de culturi celulare

PREGATIRE BIOMEDICALA AVANSATA

  • Program doctoral in biologia celulara si moleculara
  • Pregatire postdoctorala a cercetatorilor din tara si din strainatate
  • Congrese nationale si international ale Societatii Romane de Biologie Celulara
  • Scoala de studii avansate anuala “De la biologia celulara si moleculara la medicina secolului 21”, sub auspiciile Academiei Romane.

 

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