DEP
GENERAL RESEARCH TOPIC
Our studies are focused on the cellular and molecular mechanisms underlying pathophysiological and physiological processes in the cardiovascular system and the discovery of non-invasive biomarkers with diagnostic and prognostic value for cardiovascular disease, to define new therapeutic approaches for atherosclerosis regression and prevention of cardiovascular disease events.
An integrated approach from animal models and cell cultures to preclinical studies for pathophysiological and pharmacological investigations is used.
CURRENT RESEARCH INTERESTS
• Extracellular vesicles as biomarkers, biological vectors for microRNAs and biomedical tools modulating atherosclerosis: therapeutic potential of the extracellular vesicles released from adipose tissue derived stem cells and bone marrow mesenchymal stem cells on atherosclerosis-induced vascular dysfunction and cardiac hypertrophy
• Microvesicle-associated and circulating microRNAs as potential biomarkers in diabetic dyslipidemia and targets for therapeutic approaches to protect against atherosclerosis and cardiovascular diseases
• Microvesicles and platelets as regulators of T-cell function in experimental induced atherosclerosis: exploration of the molecular mechanisms underlying the miRNA-mediated modulation of T-cell functions
• Exosomes derived from neutrophils undergoing netosis as players in modulation of the cardiac fibroblast-to-myofibroblast transition in cardiac fibrosis: investigation of responsible mechanisms and reliable markers to identify cardiac myofibroblasts
• Vascular wall damage in atherosclerotic cardiovascular disease and cardiopulmonary disease: molecular mechanisms involved and effects of extracellular vesicle- and siRNA-mediated therapy
• Mitochondrial dysfunction in atherosclerosis: mechanisms involved and therapeutic strategies
RESEARCH TEAM
Dr. Habil Adriana Georgescu
Scientific Researcher Grade I, Head of Department
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Dr. Gabriela Tanko Scientific Researcher Grade II CV-link |
Dr. Nicoleta Alexandru-Moise, Scientific Researcher Grade II |
Dr. Alina Constantin Scientific Researcher Grade III
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Dr. Miruna Andreea Nemecz Scientific Researcher Grade III |
Ioana-Karla Comarița PhD Student, Research Assistant |
Marilena Isachi Technical assistant
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Former research staff: Dr. Academician Doina Popov, Head of the Department 1979-2016
Former team members: Mirela Enache, Mirela Hasu, Alexandra Vulpanovici, Adina Mihai, Ana Maria Grigore, Mădălina Dumitrescu, Marcela Toader, Alexandru Filippi, Alexandra Vîlcu
FORMATION ACTIVITIES
DOCTORAL STUDIES/PhD PROGRAM
• 2020-present - Ioana Karla Comarița, PhD supervisor: PhD Habil Adriana Georgescu
• 2020-present - Alexandra Vîlcu, PhD supervisor: PhD Habil Adriana Georgescu
POSTDOCTORAL PROGRAM
•2020-2022 – Dr. Natalia Simionescu - PD Grant, Project no. PN-III-P1-1.1-PD-2019-0283/Contract no. 155/2020, “Microvesicle - associated microRNAs as new potential biomarkers for risk prediction and early diagnosis of glioblastoma recurrence”, Acronym: MICROGLIO, 53192 Euro. Mentor for the project: Dr. Habil Adriana Georgescu
• 2018-2020 – Dr. Florin Iordache - PD Grant, Project no. PN-III P1-1.1-PD2016-1660/ Contract no. 19/2018, “Tissue engineering of blood vessels using three-dimensional bioprinting of endothelial and smooth muscle progenitor cells”. Acronym: BIOPRINT, 53192 Euro. Mentor for the project: Dr. Habil Adriana Georgescu
PUBLICATIONS
PUBLISHED PAPERS IN ISI JOURNALS WITH IMPACT FACTOR (IN THE LAST TEN YEARS)
2024
• Comarița I. K., Tanko G., Anghelache I.L., Georgescu A. The siRNA-mediated knockdown of AP-1 restores the function of the pulmonary artery and the right ventricle by reducing perivascular and interstitial fibrosis and key molecular players in cardiopulmonary disease. J Transl Med.; 22(1):137, 2024. doi: 10.1186/s12967-024-04933-1. IF: 8.440, Q1
2023
• Badila E., Japie C., Vrabie A.-M., Badila A., Georgescu A. Cardiovascular disease as a consequence or a cause of cancer: potential role of extracellular vesicles. Biomolecules, 13: 321-349, 2023. https://doi.org/10.3390/ biom13020321. IF: 6.064, Q2
• Daian L. M., Tanko G., Vacaru A.M., Ghila L., Chera S., Vacaru A.-M. Modulation of Unfolded Protein Response Restores Survival and Function of β-Cells Exposed to the Endocrine Disruptor Bisphenol A. International Journal of Molecular Sciences, 24(3), 1-23, 2023. FI:5,6, Q1
• Nemecz M., Stefan D.S., Comarița I.K., Constantin A., Tanko G., Guja C., Georgescu A. Microvesicle-associated and circulating microRNAs in diabetic dyslipidemia: miR-218, miR-132, miR-143, and miR-21, miR-122, miR-155 have biomarker potential. Cardiovascular Diabetology, 22(1):260-291, 2023. IF: 9,3, Q1
• Popov L.D. Mitochondria as intracellular signalling organelles. An update. Cell Signal. 109:110794, 2023. doi: 10.1016/j.cellsig.2023.110794. IF: 4.85, Q1
• Scafa Udriște A., Niculescu A.-G., Iliuță L., Bajeu T., Georgescu A. Grumezescu A. M., Bădilă E. Progress in Biomaterials for Cardiac Tissue Engineering and Regeneration. Polymers, 15:1177-1200, 2023. https://doi.org/10.3390/polym15051177 IF:5, Q1
2022
• Alexandru N., Procopciuc A., Vîlcu A., Comariţa I.K., Badila E., Georgescu A. Extracellular Vesicles—Incorporated MicroRNA Signature as Biomarker and Diagnosis of Prediabetes State and Its Complications. Rev. Endocr. Metab. Disord. 2022, 23, 309–332, doi:10.1007/s11154-021-09664-y, IF 9.306, Q1
• Comariţa I.K., Vîlcu A., Constantin A., Procopciuc A., Safciuc F., Alexandru N., Dragan E., Nemecz M., Filippi A., Chiţoiu L., Gherghiceanu M., Georgescu A. Therapeutic Potential of Stem Cell-Derived Extracellular Vesicles on Atherosclerosis-Induced Vascular Dysfunction and Its Key Molecular Players. Front. Cell Dev. Biol. 2022, 10, doi:10.3389/fcell.2022.817180, IF: 6.684, Q1
• Constantin A., Comarița I.K., Alexandru N., Filippi A., Bojin F., Gherghiceanu M., Vîlcu A., Nemecz M., Niculescu L.S., Păunescu V., Georgescu A. Stem Cell‐derived Extracellular Vesicles Reduce the Expression of Molecules Involved in Cardiac Hypertrophy—In a Model of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Front. Pharmacol. 2022, 13, doi:10.3389/fphar.2022.1003684, IF: 5.988, Q1
• Filippi A., Constantin A., Alexandru N., Mocanu C.A., Vlad M.L., Fenyo I.M., Simionescu A., Simionescu D., Manduteanu I., Georgescu A. VLA4‐Enhanced Allogeneic Endothelial Progenitor Cell‐Based Therapy Preserves the Aortic Valve Function in a Mouse Model of Dyslipidemia and Diabetes. Pharmaceutics, 2022, 14(5), 1077, doi:10.3390/pharmaceutics14051077, IF: 6.525,Q1
• Popov L.-D. Deciphering the Relationship between Caveolae-Mediated Intracellular Transport and Signalling Events. Cell. Signal. 2022, 97, 110399, doi:10.1016/j.cellsig.2022.110399, IF: 4.85, Q1
• Popov, L.-D. Mitochondrial-Derived Vesicles: Recent Insights. J. Cell. Mol. Med. 2022, 26(12), 3323–3328, doi:10.1111/jcmm.17391, IF: 5.295, Q1
• Simionescu N., Nemecz, M., Petrovici A.-R., Nechifor I.S., Buga R.-C., Dabija M.G., Eva L., Georgescu A. Microvesicles and Microvesicle-Associated MicroRNAs Reflect Glioblastoma Regression: Microvesicle-Associated MiR-625-5p Has Biomarker Potential. Int. J. Mol. Sci. 2022, 23(15), 8398, doi:10.3390/ijms23158398, IF: 6.208, Q1
• Voicu G., Rebleanu D., Mocanu C.A., Tanko G., Droc I., Uritu C.M., Pinteala M., Manduteanu I., Simionescu M., Calin M. VCAM-1 Targeted Lipopolyplexes as Vehicles for Efficient Delivery of ShRNA-Runx2 to Osteoblast-Differentiated Valvular Interstitial Cells; Implications in Calcific Valve Disease Treatment. Int. J. Mol. Sci. 2022, 23(7), 3824, doi:10.3390/ijms23073824, IF: 6.208, Q1
2021
• Dumitrescu M., Constantin A., Nemecz A. M., Drăgan E., Popov L.D., Tanko G. Hypertension induces compensatory left ventricular hypertrophy by a mechanism involving gap junction lateralization and overexpression of CD36, PKC and MMP-2. Romanian Journal of Morphology and Embryology, Open Access, Volume 62, Issue 3, Pages 713 – 721, 2021. IF: 0.833, Q3
• Georgescu A., Simionescu M. Extracellular Vesicles: Versatile nanomediators, potential biomarkers and therapeutic agents in atherosclerosis and COVID-19-related thrombosis. International Journal of Molecular Sciences, 22(11): 5967-5994, 2021. https://doi.org/10.3390/ijms22115967 IF:5.92, Q1
• Popov L-D. One step forward: extracellular mitochondria transplantation, Cell and Tissue Research, 384 (3): 607-612, 2021. DOI:10.1007/s00441-021-03428-510.1007/s00441-021-03428-5. IF: 5.027, Q1
• Simionescu N., Zonda R., Petrovici A-R., Georgescu A. The multifaceted role of extracellular vesicles in glioblastoma: microRNA nanocarriers for disease progression and gene therapy. Pharmaceutics, 13(7): 988-1015,2021. IF: 6.32, Q1
2020
• Alexandru N., Andrei E., Safciuc F., Dragan E., Balahura A.M., Badila E., Georgescu A. Intravenous administration of allogenic cell-derived microvesicles of healthy origins defends against atherosclerotic cardiovascular disease development by a direct action on endothelial progenitor cells. Cells, 9(2):423-447, 2020. IF 6.656, Q1
• Constantin* A., Filippi*A., Alexandru N., Nemecz M., Georgescu A. Extracellular vesicles from adipose tissue stem cells in diabetes and associated cardiovascular disease; pathobiological impact and therapeutic potential. International Journal of Molecular Sciences (IJMS), 21 (24): 9598-9623, 2020, doi:10.3390/ijms21249598 (†These authors contributed equally to this work) IF: 4.556, Q1
• Gheorghe R.-O., Deftu A., Filippi A., Grosu A., Bica-Popi M., Chiritoiu M., Chiritoiu G., Munteanu C., Silvestro L., Ristoiu V. Silencing the cytoskeleton protein Iba1 (ionized calcium binding adapter protein 1) interferes with BV2 microglia functioning.Cellular and molecular neurobiology, 40:1011-1027, 2020. IF: 3.606, Q1
• Filippi A., Constantin A., Alexandru N., Voicu G., Constantinescu C.A., Rebleanu D., Fenyo M., Simionescu D., Simionescu A., Manduteanu I., Georgescu A. Integrins α4β1 and αVβ3 are Reduced in Endothelial Progenitor Cells from Diabetic Dyslipidemic Mice and May Represent New Targets for Therapy in Aortic Valve Disease. Cell Transplantation, 29:1-8, 2020. IF 3.341, Q2
• Picu A. , Petcu L., Stefan D.S., Gradisteanu Pircalabioru G., Mitu M., Bajko D., Lixandru D., Guja C., Savu O., Pantea Stoian A., Constantin A., Smeu B., Copaescu C., Chifiriuc M.C., Ionica E., Ionescu-Tirgovişte C. Evolution of Inflammatory and Oxidative Stress Markers in Romanian Obese Male Patients with Type 2 Diabetes Mellitus after Laparoscopic Sleeve Gastrectomy: One Year Follow-Up. Metabolites 10(8):308-322, 2020. IF: 3.303, Q2
• Popov L.D. Mitochondrial biogenesis: An update. J Cell Mol Med 24(9):4892-4899, 2020. IF 4.486, Q1
2019
• Alexandru N., Safciuc F., Constantin A., Nemecz M., Tanko G., Filippi A., Dragan E., Bãdilã E., Georgescu A. Platelets of healthy origins promote functional improvement of atherosclerotic endothelial progenitor cells. Frontiers in Pharmacology/Inflammation Pharmacology 10 (article 424):1-14, 2019. IF: 3.84, Q1
• Alexandru N., Constantin A., Nemecz M., Comarița I.K., Vîlcu A., Procopciuc A., Tanko G., Georgescu A. Hypertension associated with hyperlipidemia induced different microRNA expression profiles in plasma, platelets, and platelet-derived microvesicles; effects of endothelial progenitor cell therapy. Frontiers in Medicine, doi: 10.3389/fmed.2019.00280, 6:280-290, pages 1-10, 3 December 2019. IF: 3.9, Q1
• Constantin A., Dumitrescu M., Nemecz M., Picu A., Smeu B., Guja C., Alexandru N., Georgescu A., Tanko G. Sera of Obese Type 2 Diabetic Patients Undergoing Metabolic Surgery Instead of Conventional Treatment Exert Beneficial Effects on Beta Cell Survival and Function: Results of a Randomized Clinical Study. Obesity Surgery, 1-13, 2019. IF: 3.60, Q1
• Iosif L., Lixandru D., Gaman L., Ilie M., Smeu B., Ştefan D. S., Petcu L., Picu A., Constantin A., Ionescu-Tîrgovişte C., Guja C., Copăescu C. Oxidative stress profile and type 2 diabetes remission at 6 months after sleeve gastrectomy versus conservatory treatment. Farmacia Open AccessVolume 67, Issue 1, Pages 99 – 105, 2019. IF: 1.607, Q2
• Nemecz M., Constantin A., Dumitrescu M., Alexandru N., Filippi A., Tanko G., Georgescu A. The distinct effects of palmitic and oleic acid on pancreatic beta cell function: the elucidation of associated mechanisms and effector molecules. Frontiers in Pharmacology/Ethnopharmacology, 9 (article1554):1-16, 2019. IF 3.84, Q1
• Popov L.D. Mitochondrial peptides-appropriate options for therapeutic exploitation. Cell Tissue Res. 377:161-165,. 2019. IF 3.34, Q1
• Tucureanu*M.M., Filippi* A., Alexandru N., Constantinescu C.A., Ciortan L., Macarie R., Vadana M., Voicu G., Frunza S., Nistor D., Simionescu A., Simionescu D.T., Georgescu** A.(corresponding author), Manduteanu I. Diabetes-induced early molecular and functional changes in aortic heart valves in a murine model of atherosclerosis, Diabetes and Vascular Disease Research, 16(6):562-576, 2019, doi: 10.1177/1479164119874469. (*These authors contributed equally to this work). IF:3.34, Q3
2018
• Deftu A.F., Filippi A., Gheorghe R.O., Ristoiu V. CXCL1 activates TRPV1 via Gi/o protein and actin filaments. Life Sciences, 193, 282-291, 2018. IF: 3.23, Q1
• Georgescu A. Understanding the functional role of microRNA-214-3p in atherosclerosis for the identification of novel targeted therapies to prevent or reverse endothelial cell dysfunction and stimulate autophagy. Acta Physiologica, 222(3), 2018. doi: 10.1111/apha.12997. IF: 5.93,Q1
• Popa M.A., Mihai M.C., Constantin A., Şuică V., Ţucureanu C., Costache R., Antohe F., Dubey R.K., Simionescu M. Dihydrotestosterone induces pro-angiogenic factors and assists homing of MSC into the cardiac tissue. J Mol Endocrinol, 60(1):1-15, 2018. IF: 4.869, Q1
• Popov L.D. Mitochondrial dysfunction signature in diabetic vascular endothelium. J Clin Exp Pathol, 8(1): 334, 2018. IF: 1.57
• Stępień EŁ, Durak-Kozica M., Kamińska A., Targosz-Korecka M., Libera M., Tylko G., Opalińska A., Kapusta M., Solnica B., Georgescu A., Costa M.C., Czyżewska-Buczyńska A., Witkiewicz W., Małecki M.T., Enguita F.J. Circulating ectosomes: Determination of angiogenic microRNAs in type 2 diabetes. Theranostics 8(14): 3874-3890, 2018. IF: 8.71, Q1
2017
• Alexandru N., Andrei E., Niculescu L., Dragan E., Ristoiu V., Georgescu A. Microparticles of healthy origins improve endothelial progenitor cell dysfunction via microRNA transfer in an atherosclerotic hamster model. Acta Physiologica. 221: 230–249, 2017. doi: 10.1111/apha.12896. IF:5.93, Q1
• Alexandru N., Costa A., Constantin A., Cochior D., Georgescu A. Microparticles: From biogenesis to biomarkers and diagnostic tools in cardiovascular disease. Current Stem Cell Research& Therapy. 2017;12(2):89-102. doi: 10.2174/1574888X11666151203224058. IF: 2.645, Q2
• Ciotu I.M., Constantin A., Voinea L., Atansiu V. Matrix mettaloproteinase and their inhibitors concentration and activity variations in aqueous humor and plasma of glaucoma patients. Revista de Chimie. 2017; 68:1829-1832. IF: 1.232
• Constantin A., Dumitrescu M., Mihai (Corotchi) M.C., Jianu D., Simionescu M. CO2 laser increases the regenerative capacity of human adipose-derived stem cells by a mechanism involving the redox state and enhanced secretion of pro-angiogenic molecules. Lasers in Medical Science. 2017 Jan;32(1):117-127. doi: 10.1007/s10103-016-2093-6. Epub 2016 Oct 20. IF: 1.949, Q2
• Popov L.-D. Mitochondrial networking in diabetic left ventricle cardiomyocytes. Mitochondrion. 2017 May;34:24-31. doi: 10.1016/j.mito.2016.12.002. Epub 2016 Dec 19. IF: 4.35, Q1
Titorencu I., Albu MG., Nemecz M., Jinga VV. Natural polymer-cell bioconstructs for bone tissue engineering, Current Stem Cell Research & Therapy, 12(2): 165-174, 2017. doi: 10.2174/1574888X10666151102105659. IF: 2.65, Q2
2016
• Alexandru N., Badila E., Weiss E., Cochior D., Stępień E., Georgescu A. Vascular complications in diabetes: Microparticles and microparticle associated microRNAs as active players. Biochem Biophys Res Commun. 2016 Mar 25;472(1):1-10. doi: 10.1016/j.bbrc.2016.02.038. Epub 2016 Feb 15. Review. PMID:26891868. IF: 2.462, Q2
• Georgescu* A., Alexandru* N., Andrei E., Dragan E., Cochior D., Dias S. Effects of transplanted circulating endothelial progenitor cells and platelet microparticles in atherosclerosis development. Biology of the Cell, 2016 Aug;108(8):219-43. doi: 10.1111/boc.201500104. Epub 2016 Apr 24. PMID:26968123. (*These authors contributed equally to this work).IF:3.506, Q2
• Nemecz* M., Alexandru*N., Tanko G., Georgescu A. Role of microRNA in endothelial dysfunction and hypertension. Current Hypertension Reports, 2016 Dec; 18(12):87. (*These authors contributed equally to this work). doi: 10.1007/s11906-016-0696-8. IF:3.112,Q2
• Simion V., Stan D., Constantinescu C.A., Deleanu M., Dragan E., Tucureanu M.M., Gan A.M., Butoi E., Constantin A., Manduteanu I., Simionescu M., Calin M. Conjugation of curcumin-loaded lipid nanoemulsions with cell-penetrating peptides increases their cellular uptake and enhances the anti-inflammatory effects in endothelial cells. J Pharm Pharmacol. 2016 Feb;68(2):195-207. IF:2.39
2015
• Alexandru N., Andrei E., Dragan E., Georgescu A. Interaction of platelets with endothelial progenitor cells in the experimental atherosclerosis; the role of transplanted endothelial progenitor cells and platelet microparticles. Biology of The Cell, 107: 189–204, 2015. IF: 3.87, Q2
• Bãdilã E., Daraban A.M., Ţintea E., Bartoş D., Alexandru N., Georgescu A. Midkine in cardio-vascular disease: Where do we come from and where are we heading to? European Journal of Pharmacology, 762:464-471, 2015. IF: 2.68, Q2
• Manea A., Manea S.A., Gan A.M., Constantin A., Fenyo I.M., Raicu M., Muresian H., Simionescu M. Human monocytes and macrophages express NADPH oxidase 5; a potential source of reactive oxygen species in atherosclerosis.Biochem Biophys Res Commun. 22;461(1):172-9, 2015. IF: 2.985, Q2
• Manea S.A., Constantin A., Manda G., Sasson S., Manea A. Regulation of Nox enzymes expression in vascular pathophysiology: focusing on transcription factors and epigenetic mechanisms. Redox Biology. vol 25 (5), pag 358-366, 2015. IF: 6.337, Q1
• Orbe J., Alexandru N., Roncal C., Belzunce M., Bibiot P., Rodriguez J.A., Meijers J.C.M., Georgescu A., Paramo J.A. Lack of TAFI increases brain damage and microparticle generation after thrombolytic therapy in ischemic stroke. Thrombosis Research,136(2): 445-450, 2015. IF: 2.42, Q2
2014
• Andrei E., Alexandru N., Dragan E., Georgescu A. Flow cytometric analysis of circulating microparticles and endothelial progenitor cells in plasma; a research tool for atherosclerosis and therapy. Experimental and Clinical Cardiology, 20 (7): 1554-1563, 2014. IF: 1.10, Q3
• Bădila E., Daraban A. M., Ghiorghe S., Georgescu A., Alexandru N., Bartoş D., Tîrziu C. Rethinking cardiovascular therapy - the effect of irbesartan on circulating microparticles and endothelial progenitor cells in patients with hypertension and dyslipidemia. Farmacia, 62 (1): 93-106, 2014. IF: 1.25, Q2
• Popov D., Protein S-glutathionylation: from current basics to targeted modifications, Arch Physiol Biochem, 2014, doi:10.3109/13813455.2014.944544, PMID: 25112365.
PUBLISHED PAPERS IN JOURNALS INDEXED IN INTERNATIONAL DATABASES (IN THE LAST TEN YEARS)
• Popov L.D. Mitochondria - hypertension relationship, a novel ground for crossing the therapy frontier.J Hypertens Res, 5(4):143–147, 2019.
• Costa A., Alexandru N., Silva F., Magalhães A., Dias S., Georgescu A. Detection of miRNAs in Extracellular Vesicles by In Situ Hybridization Using Formalin-Frozen Paraffin Embedded Sections. Annals of R.S.C.B., Vol. XXI, Issue 3, 2017, pp. 29 - 35 doi: 10.ANN/RSCB-2017-0019: RSCB, 2018.
• Alexandru N., Georgescu A. Microparticles as players in the pathogenesis of cardiovascular disease. Fisiología, vol. 18(1):9-14, 2015. ISSN:1889-397X.
• Andrei E., Alexandru N., Georgescu A. Circulating microparticles: major mediators of the pathogenesis of cardiovascular complications in diabetes. Annals of the Romanian Society for Cell Biology, vol. XIX, Issue 3, pp. 55-63, 2015.
• Nemecz M., Dumitrescu M., Constantin A., Titorencu I., Tanko G., Popov D. Catalase reduces PDGF-mediated vascular SMCs proliferation in high glucose conditions,Annals of RSCB, XIX(3): 95-103, 2015.
• Tokarz A., Szuścik I., Kuśnierz-Cabala B., Kapusta M., Konkolewska M., Żurakowski A., Georgescu A., Stępień E. Extracellular vesicles participate in the transport of cytokines and angiogenic factors in diabetic patients with ocular complications. FOLIA MEDICA CRACOVIENSIA, PL ISSN 0015-5616, Vol LV, 4, 35–48, 2015.
• Alexandru N., Badila E., Georgescu A. The role of endothelial progenitor cells in the cardiovascular disease pathogenesis. J Stem Cells Res, Rev & Rep.1(2):1-2, 2014.
SCIENCE NEWSPAPER ARTICLE
• Alexandru N., Georgescu A. Active role of cell-derived microparticles
in diabetes associated cardiovascular complications. Atlas of Science (website: www.atlasofscience.org), August 12, 2016.
EDITED SPECIAL ISSUES
• Georgescu A. - ACADEMIC GUEST EDITOR for Special Issue "Recent Advances in Cellular and Molecular Mechanisms of Cardiovascular and Metabolic Diseases: 2nd Edition". Biomolecules (ISSN 2218-273X), Section "Cellular Biochemistry", 2024. IF: 4.8, Q2
• Georgescu A. - ACADEMIC GUEST EDITOR for Special Issue "Recent Advances in Cellular and Molecular Mechanisms of Cardiovascular and Metabolic Diseases". Biomolecules (ISSN 2218-273X), Section "Cellular Biochemistry", 2022/2023. IF: 6.064, Q2
BOOKS
- • Simionescu M., Calin M., Georgescu A. An incredible 40-year journey to understand cell’s secrets for the benefit of human health. National Foundation for Science and Art 978-606-555-270-8, pp. 1-223, 2019.
- • Georgescu A. Cardiovascular Dysfunction: New Biomarkers and Therapies. Published by Scholars' Press, OmniScriptum GmbH & Co. KG, Saarbrücken, Germany, ISBN -978-3-639-71643-6, pp. 1-170, 2014.
- • Georgescu A., Antohe F. Editor of the international monograph ‘From Vascular Cell Biology to Cardiovascular Medicine’, published by Research Signpost /Transworld Research Network, Trivandrum - 695023, Kerala, India, ISBN-978-81-7895-503-2, 2011.
- • Alexandru N.. Platelet dysfunction during ageing and in cardiovascular pathology (in Romanian), Agir Editorial House, Bucharest, Romania, 159 pages, ISBN: 978-973-720-289-5, 2010.
- • Simionescu M., Sima A., Popov D., (eds.) “Cellular Dysfunction in Atherosclerosis and Diabetes-Reports from Bench to Bedside” Romanian Academy Publishing House, 426 pages, ISBN: 973-27-1100-0, 2004.
CHAPTERS IN BOOKS
• Gherghiceanu M., Alexandru N., Magda S.L., Constantin A., Nemecz M., Filippi A., Ioghen O.C., Ceafalan L.C., Bojin F., Tanko G., Paunescu V., Vinereanu D., Stepien E., Georgescu A. Chapter's Title: Extracellular vesicles as valuable players in diabetic cardiovascular diseases. Published: 30 May 2019. Book title: Extracellular Vesicles and Their Importance in Human Health, Book edited by: Dr. Ana Gil De Bona and Jose Antonio Reales-Calderon, IntechOpen, ISBN 978-1-78923-944-7, p.1 -25, 2020.
• Ceafalan L.C., Ioghen O.C., Marta D.S., Constantin A., Alexandru N., Nemecz M., Tanko G., Filippi A., Magda S.L., Bojin F., Paunescu V., Vinereanu D., Georgescu A., Gherghiceanu M. Chapter's Title: Extracellular Vesicles as Risk Factor in Neurodegenerative Diseases. Published: 05 July 2019. Book's Title: Extracellular Vesicles and Their Importance in Human Health, Book edited by: Dr. Ana Gil De Bona and Jose Antonio Reales-Calderon, IntechOpen, ISBN 978-1-78923-944-7, p.1 -21, 2020.
• Alexandru N., Titorencu I., Frunzã S., Weiss E., Bãdilã E., Georgescu A. Chapter's Title: Endothelial progenitor cell dysfunction in the pathogenesis of vascular complications of diabetes. Book's Title: Mechanisms of Vascular Defects in Diabetes Mellitus, Editors: ChandrasekharanKartha, Surya Ramachandran, M. Radhakrishna Pillai, in Series Title: Advances in Biochemistry in Health and Disease, Springer, UK, Volume 17, ISBN 978-3-319-60324-7, p.159-208, 2017.
• Lucia-Doina Popov, Cardiologia moleculară: prezent și potențial terapeutic. Capitolul 7 în tratatul Cardiologie clinica, editor E. Apetrei, Editura Medicală CALLISTO, ISBN: 9786068043180, p. 95-108, 2015.
• Georgescu A., Alexandru N., Popov D. Ongoing data on vascular endothelial cell dysfunction: an update, in a book entitled: From Vascular Cell Biology to Cardiovascular Medicine, Editors: A. Georgescu and F. Antohe, published by RESEARCH SIGNPOST/TRANSWORLD RESEARCH NETWORK,Kerala, India, ISBN - 978-81-7895-503-2, p. 125-141,2011.
• Popov D. Towards understanding the mechanisms of impeded vascular function in diabetic kidney. In: “Cellular Dysfunction in Atherosclerosis and Diabetes - Reports from Bench to Bedside”, eds. Simionescu M., Sima A., Popov D., Romanian Academy Publishing House, p.244-258, 2004.
• Simionescu M., Popov D., Sima A. Endothelial dysfunction in diabetes. In: “Vascular Involvement in Diabetes: Clinical, Experimental and Beyond”, D.M. Cheta (ed.), The Publishing House of the Romanian Academy, pp. 15-34, 2004.
• Popov D., Radu D.L. The role of hyperglycemia in the development of diabetic complications investigated in transgenic mouse model. In: “Vascular Involvement in Diabetes: Clinical, Experimental and Beyond” (D.M. Cheta, editor), The Publishing House of the Romanian Academy, pp. 120-134, 2004.
• Popov D., Costache G., Georgescu A. Altered vascular reactivity of the resistance arteries: lessons from the hyperlipemic-hyperglycemic hamster model, in "New Insights into experimental Diabetes", D. M. Cheta (Ed.), The Publishing House of the Romanian Academy, ISBN: 973-27-0871-9, 211-222, 210-222, 2002.
• Simionescu M., Popov D., Sima A. Cellular and molecular alterations in diabetes – induced cardiovascular complications studied in an original experimental model, in “New Insights into experimental Diabetes”, D.M. Cheta (ed.), The Publishing House of the Romanian Academy, ISBN: 973-27-0871-9, 211-222, 173-209, 2002.
• Popov D., Simionescu M. Structural and transport property alterations of the lung capillary endothelium in diabetes. In: Advances in Microanatomy of Cells and Tissues, Biophysical and Biochemical Correlates, P.M. Motta, G. Macchiarelly, S.A. Nottola (eds.), Italian J. Anatomy and Embryology, 106 (supplement 1), No. 2, p. 405-412, 2001.
PATENTS
• Process for obtaining the genetically modified endothelial progenitor cells (Procedeu de obtinere a unor celule progenitoare endoteliale modificate genetic). Patent Application: OSIM Nr. A/00284 din 25.05.2020. Authors: Alexandru Filippi, Loredana Antonescu, Alina Constantin, Cristina Constantinescu, Nicoleta Alexandru, Adriana Georgescu.
• Process for obtaining modified extracellular vesicles (Procedeu de obținere a veziculelor extracelulare modificate). Patent Application, OSIM No. A/00017 of 20.01.2021. Authors: Alexandru Filippi, Nicoleta Alexandru-Moise, Alina Constantin, Karla Comarita, Alexandra Vîlcu, Anastasia Procopciuc, Adriana Georgescu.
GRANTS
INTERNATIONAL GRANTS
• 2016-2020 Competitiveness Operational Programme Grant, code SMIS: 104362, Contract no. 115/13.09.2016, “Targeted therapies for diabetes - related aortic valve disease’’. Acronym: THERAVALDIS, 8657500 lei. Specialist in implementation Project team: PhD Adriana Georgescu; Executive Manager: Acad. Ileana Mânduțeanu; Project Manager: PhD Agneta Simionescu; Project leader: PhD Agneta Simionescu, Clemson University, USA
• 2012-2014 Capacity project: ERC-like – type "Grant Support", ID PNII-CT-ERC-2012–1. “Circulating platelet microparticles and endothelial progenitor cells in vascular atherosclerosis: new pathophysiological and therapeutic implications”.Grant nr.6/18.07.2012; 1 500 000 RON. Project manager: PhD Adriana Georgescu
• 2008-2011 COST Programme EU COST Action BM 0602. “Adipose tissue cells dialogue in obesity, diabetes and inflammation; search for molecules of pharmacological potential in reducing adipose tissue inflammatory proteins”. Project manager: Acad. Doina Popov, Institute of Cellular Biology and Pathology –‘N. Simionescu’
• 2005-2008 Specific Support Action, PC6, SERA Project, No. 016873. "Strengthening the European Research Area by Reinforcement of Romanian Research Competency in Genomics and Proteomics of Major Global Risk Diseases: Atherosclerosis, Diabetes and its Complications". Project manager: Acad. Maya Simionescu, Institute of Cellular Biology and Pathology –‘N. Simionescu’
• 2001-2002 Grant from the Deutsche forschungsgemeinschaft (Dfg). Grant in collaboration with Institute of Pharmacy and Food Chemistry, Friedrich-AlexanderUniversity Erlangen-Nuremberg, Erlangen, Germany, “Detection of non-enzymatic glycation products of cellular ADN using experimental models of diabetic animals”. Project manager: PhD Adriana Georgescu
NATIONAL GRANTS
• 2023-2026 PNRR Program Grant, codePNRR-III-C9-2022–I8-CF93. “New nanotherapeutic strategies for cardiac fibrosis targeting the mechanisms underlying the fibroblast to myofibroblast transition”. Acronym: HeartCure, 7.678.795,14 lei. Project Manager: Prof Rostyslav Bilyy. Principal Investigators IBPC-N. Simionescu: PhD Manuela Calin, PhD Adriana Georgescu, PhD Elena Butoi
• 2023-2026 PNRR Program Grant, codePNRR-III-C9-2022–I8-CF258.“Strengthening the Romanian competency in metabolic syndrome research by exploring the role of apolipoprotein A2 in dyslipidemia, obesity and type II diabetes mellitus”. Acronym: STOMA, 7.606.842,14 lei. Project Manager: PhD Kyriakos E. Kypreos. Principal Investigator IBPC-‘N. Simionescu’: PhD Anca Gafencu
• 2019-2023 NO Grants, code RO-NO-2019-0544, Project contract no. 21/2020. “Supportive therapy for diabetes by increasing the stress endurance and regenerative capacity of β-cells. Acronym: BETAUPREG, 1.185.000 Euro. Project manager: PhD Ana-Maria Vãcaru, Institute of Cellular Biology and Pathology ‘N. Simionescu’
•2020-2022 Young Teams Research Grant, code PN-III-P1-1.1-TE-2019-0811,Grant no 97 /04.09.2020, “Immune modulation of T-cells by platelets and platelet-derived microvesicles in experimental induced atherosclerosis; the role of microRNA-142-3p”, Acronym: IMPLEXIA,431 900 lei. Project manager: PhD Nicoleta Alexandru
• 2018-2021 PCCDI Grant, code PN-III-P1-1.2-PCCDI-2017-0527/Contract no. 83 PCCDI/2018, “Development of BIOnanotechnologies based on extracellular vesicles for early diagnosis, prognosis and therapy of atherosclerotic disease”. Acronym: BIOVEA, 5.625,000 lei. Partners: National Institute for Research and Development in the field of Pathology and Biomedical Sciences "Victor Babeş" Bucharest (INCDVB); University of Medicine and Pharmacy "Carol Davila" Bucharest (UMFCD); Emergency Clinical Hospital "Pius Brînzeu" Timişoara - Research Center OncoGen (OncoGen). Project manager: PhD Adriana Georgescu
• 2018-2021 PCCDI Grant, code PN-III-P1-1.2-PCCDI-2017-0797/ Contract no. 66 PCCDI/2018, “Pathogenic mechanisms and personalized treatment in pancreatic cancer using multi-omics technologies”. Acronym: PANCNGS. Partners: University of Bucharest, Faculty of Biology: Department of Anatomy, Physiology and Biophysics; University of Medicine and Pharmacy, Craiova; IBPC-‘N. Simionescu’. Project manager: M.D., I. Popescu, Fundeni Clinical Institute, Bucharest, Project responsible IBPC: Acad. Maya Simionescu
• 2018-2020 PCCDI Grant, code PN-III-P1-1.2-PCCDI-2017-0749/Contract no. 45 PCCDI/2018, “Bioactive nanostructures for innovative therapeutic strategies”. Acronym: NANO-LIFE. Project manager: Prof. Dr Laurentiu Mogoanta, University of Medicine and Pharmacy, Craiova, Partners: Politehnica University of Bucharest; Carol Davila University of Medicine and Pharmacy; Institute of Cellular Biology and Pathology –“N. Simionescu”
•2015-2017 Young Teams Research Grant, codePN-II-RU-TE-2014-4-0525, Grant no 79/01.10.2015, “Microparticles as intracellular delivery strategies for microRNAs and potential therapies for atherosclerotic vascular disease”, Acronym: MISTAD, 550 000 lei. Project manager: PhD Adriana Georgescu
• 2015-2017 Young Teams Research Grant, codePN-II-RU-TE-2014-4-0523,Grant no 80/01.10.2015, “New insights in platelet-endothelial progenitor cell interplay in atherosclerotic disease”, Acronym: NICAD, 550 000 lei. Project manager: PhD Nicoleta Alexandru
• 2014-2016 PCCA Grant, code PN-II-PT-PCCA-2013-4-2154, Contract no. 207/2014, “Developing a protocol for selecting patients with obesity and type 2 diabetes mellitus (T2DM) eligible for diabetes remission after metabolic surgery”, Acronym: CREDOR. Project manager: M.D., Cãtãlin Copãiescu, Regina Maria Hospital, Ponderas Hospital, Bucharest, Project responsible IBPC: PhD Gabriela Costache
• 2014-2016 PCCA Grant, code PN-II-PT-PCCA-2013-4-2267,”Biodegradable implants from magnesium alloys used in foot and knee surgery”. Project manager: PhD Iulian Antoniac, Politehnica University of Bucharest
• 2014-2016 PCCA Grant, code PN-II-PT-PCCA-2013-4-1958, ”Multifunctional coatings for load bearing implants made of novel titanium-based alloy”. Project manager: PhD Alina Vladescu, National Institute for Research and Development in Optoelectronics, Bucharest
• 2011-2014 Young Teams Research Grant, codePNII-TE 26/2011-2014, “Investigation of molecular mechanisms of endothelin system in diabetes; development of new pharmacological strategies to improve vascular function”. Project manager:PhD Simona-Adriana Manea, Institute of Cellular Biology and Pathology –‘N. Simionescu’
• 2008-2011 PARTNERSHIP PNCDI-2 Grant, Grant no. 42138/ 1.10.2008, “Ratio of circulating microparticles to endothelial progenitor cells, a new cellular marker of endothelial dysfunction induced by combined hypertension and hypercholesterolemia; anti-atherosclerotic effect of irbersartan”. Partners: Cardiology Clinic of University Emergency Hospital Floreasca. Project manager: PhD Adriana Georgescu
• 2008-2011 IDEI PNCDI-2 Grant, Grant no. 1159/19.01.2009, “Vascular complications of small arteries in patients with obesity associated or not with type 2 diabetes; the endothelial dysfunction and insulin resistance”. Project manager: PhD Adriana Georgescu
• 2008-2009 TD type PNCDI-2 Grant, code PN-II-RU-TD-2008-3,TD-50, Grant no 11/2.06.2008, “The studies of platelet dysfunction associated with vascular system changes in ageing and pathological conditions”, 42 500 lei. Project manager: PhD Nicoleta Alexandru
• 2007-2008 TD type PNCDI-2 Grant, code: TD-448, Grant no. 69GR/11.05.2007, Topic 6. “Strategies to combat cardiovascular complications in obesity: the anti-inflammatory effect of Rosiglitazone in the recovery of atheroma instability and endothelial dysfunction caused by adipokines”. Project manager: PhD Alina Constantin
• 2006-2008 Excellence Research Projects for young researchers (CEEX) Grant, Grant no. 15121/2006-2008,”The effect of elevated levels of shed membrane microparticles on the function of the peripheral veins at patients with chronic venous insufficiency”. Project manager: PhD Adriana Georgescu
•2005-2006 Grant from Romanian Academy, “Cellular senescence in the kidneys- a genetically determined process or a consequence of oxidative stress and nitrosative stress?”. Project manager: PhD. Mãdãlina Dumitrescu, Institute of Cellular Biology and Pathology –‘N. Simionescu’
• 2005-2008 Excellence Research Projects, “The alteration of the cellular and molecular mechanisms and of gene expression in the cardiovascular disease and diabetes/ obesity, the major alteration of the metabolic syndrome – the fundamental and clinical researches”. Acronym: AMCADO. Project manager: Acad. Maya Simionescu, Institute of Cellular Biology and Pathology ‘N. Simionescu’
•2004-2006 VIASAN PNCDI Grant, grant no. 422/ 6.10.2004,“Adiponectin as mediator of the insulin activated intracellular signaling - clinical implications in obesity associated with type 2 diabetes”. Project manager: PhD Alina Constantin
•2004-2006 VIASAN PNCDI Grant, grant no. 347/ 1.10.2004, “The effect of the enoxaparin (a low molecular weight heparin) in the reestablishment of the endothelial vascular dysfunctions in aging and in diabetes; the involvement of the mitogen-activated protein kinase evidentiated by changes in the expression of c-fos gene and transcription factor AP-1”. Project manager: PhD Adriana Georgescu
• 2003-2005 VIASAN PNCDI Grant, “Theimpact of obesity on diabetes and cardiovascular diseases generation in urban communities in Romania- a population, pathophysiological and genetic study”. Acronym: OBEDIAGEN, 60,000 Euro. Partners: National Institute for Diabetes, Nutrition and Metabolic Diseases „N. Paulescu” and Anthropology Institute „Fr. Rainer”, Project manager: Acad. Anca Sima, Institute of Cellular Biology and Pathology –‘N. Simionescu’
• 2003-2005 CERES PNCDI Grant, “The studies on the cerebral vasculature in aging”. Project manager: PhD Elena Constantinescu, Institute of Cellular Biology and Pathology –‘N. Simionescu’
• 2003-2004 VIASAN PNCDI Grant, “Possibilities for reestablishment of vascular dysfunction and biochemical changes in diabetes and atherosclerosis”. Project manager: PhD Adriana Georgescu
• 2002-2005 VIASAN PNCDI Grant, grant no. 171/ 7.10.2002, “The pharmacological properties and the cellular mechanisms involved in the effect of nebivolol in the renal artery in diabetes; the experimental data”. Project manager: PhD Adriana Georgescu
● 2002 National Consortium: Institute of Diabetes, Nutrition and Metabolic Diseases “Prof. Dr N. Paulescu”, “Cantacuzino” Institute and Institute of Cellular Biology and Pathology “N. Simionescu”, “Effect of antioxidants on carbonyl stress modulation in diabetes”. Project manager: PhD Alina Constantin
● 2001-2003 VIASAN PNCDI Grant, “The cardiovascular changes associated with type 1 diabetes at transgenic mouse model”. Project manager: PhD Doina Popov
● 2001-2002 VIASAN PNCDI Grant, grant no. 110/ 29.10.2001, “The effect of of enoxaparin sodium on the vascular reactivity of the resistance arteries in aging and in diabetes; the role of nitric oxide”. Project manager: PhD Adriana Georgescu
● 2001-2002 Grant Awarded By Romanian Research and technology Ministry, grant no. 7051/2001.”The gap junctions and the vascular reactivity of the mesenteric resistance arteries; the effect of the heptanol”. Project manager: PhD Adriana Georgescu
● 2001 MEC. “Endothelial nitric oxide synthase gene polymorphisms as potential risk factors for developing cardiovascular complications in diabetes”. Project manager: PhD Gabriela Costache
● 2000-2001. ANSTI. “A new action for clotrimazole: modulation of the vascular reactivity of the resistance arteries and of the metabolism of cells within the vascular wall”. Project manager: PhD Gabriela Costache
● 2000 Grant from Romanian Academy, Grant no. 138/ 1.10.2000. “The study of the mechanisms involved in the vascular response of the resistance arteries in the presence of bradykinine. The effect of hyperglycemiahyperlipemia on the endothelium dependent relaxation”. Project manager: PhD Adriana Georgescu
● 2000 Grant Awarded By Romanian Research and technology Ministry, Grant no. 55/ 1.12.2000. “The effect of the combined hyperglycemia –hyperlipemia on the vascular reactivity of the resistance arteries in the presence of potassium vasoconstrictor. The involved cellular mechanism”. Project manager: PhD Adriana Georgescu
• 1999-2000 Grant from Romanian Academy, Grant no. 31/ 1999. “The role of aging and of association for a long time of the hyperglycemia-hyperlipemia in the formation of the glycated irreversible proteins. The effect of the in vivo administration by Larginine”. Project manager: PhD Adriana Georgescu
● 1999 Grant Awarded By Romanian Research and technology Ministry. “The effect of simultaneously hyper-glycemiahyperlipemia on the morphological and functional changes of the organs affected in hypertension”. Project manager: PhD Doina Popov
● 1999 Grant Awarded By Romanian Research and technology Ministry, Grant no. 881/ 10.09.1999. “The effect of the simultaneously hyperglycemia –hyperlipemia on the vascular reactivity of the resistance arteries in the presence of PGF2alpha vasoconstrictor. The involved cellular mechanism”. Project manager: PhD Adriana Georgescu
AWARDS
● Prize of the Award Committee of the 44th Anniversary Symposium Of The Institute Of Cellular Biology And Pathology “Nicolae Simionescu” held jointly with 40th Annual Scientific Session Of The Romanian Society For Cell Biology, forposter presentation, Bucharest, Romania, 2023 (Ioana Karla Comarița et al.)
● Prize for Poster Presentation to “22nd World Congress of International Federation for the Surgery of Obesity and Metabolic Disorders”, London, UK, 2017 (Alina Constantin et al.)
● Prize of the Award Committee of the 3rd International Congress and 29th Annual scientific session of Romanian Society for Cell Biology, Arad (RO)-Szeged (HU), 2011 (Adriana Georgescu et al.)
● “Dr. Constantin Velican” Award of the Romanian Society for Cell Biology, 2010 (Adriana Georgescu); 2001 (Doina Popov)
● Developing World Scientist Grants of the International Society on Thrombosis and Haemostasis for the presentation at XXII Congress of International Society on Thrombosis and Haemostasis, Boston – USA, 2009 (Adriana Georgescu)
● Prize offered by Romanian Academy, Institute of Cellular Biology and Pathology “Nicolae Simionescu”, for successful scientific activities and published papers in the sixth frame work program of the European Community. Specific Support Action, INCO project. 2005-2008, SERA project, at the International Symposium Translational Research in Vascular Medicine, Bucharest, Romania, 2008 (Adriana Georgescu); 2008 (Nicoleta Alexandru)
● “Nicolae Simionescu” of the Romanian Academy, 2008 (Adriana Georgescu); 2004 (Doina Popov)
● Award offered by Romanian Academy, Institute of Cellular Biology and Pathology ‘Nicolae Simionescu’, for successful scientific activities in the sixth frame work program of the European Community. Specific Support Action, INCO project. 2005-2008, SERA project, Bucharest, Romania, 2007 (Adriana Georgescu)
● “European society on Vascular Biology and Medicine” Award for paper presentation, 4th European Meeting on Vascular Biology and Medicine, Bristol, U.K., 2007 (Adriana Georgescu)
● Second Prize at the European life scientist Organization Meeting, Nice, France, 2002 (Adriana Georgescu)
● “Young Investigator” Award of the Healthy Nutrition Foundation, 2002 (First Prize-Adriana Georgescu, Second Prize-Alina Constantin (Carale))
● “Agora Diabetologica” Award of the Romanian Society for Diabetes, Nutrition and Metabolic Diseases, Berlin-Chemie, Menarini Group and Eli Lilly, 2002 (Alina Constantin (Carale))
● “Emil Racoviță “Award of the Romanian Academy, 1991 (Doina Popov)
● Original Article Awards of the Ministry for Education and Research (45 awarded articles)
CURRENT and PAST COLLABORATIONS
INTERNATIONAL COLLABORATIONS
• 2023-2026 Lviv National Medical University, Ukraine(Prof. Rostyslav Bilyy), (PNNR Program Grant, codePNRR-III-C9-2022–I8-CF93, HeartCure);
• 2016-2020 Cardiovascular Tissue Engineering and Regenerative Medicine Lab,Clemson University, USA (Prof. Dr. Dan Teodor Simionescu), Biocompatibility and Tissue Regeneration Lab, Clemson University, USA (Prof. Dr. Agneta Simionescu), (Competitiveness Operational Programme Grant, code SMIS: 104362, Contract no. 115/13.09.2016, THERAVALDIS, resulting 3 published articles;
• 2018-2019 Department of Medical Physics, M. Smoluchowski Institute of Physics, Jagiellonian University, Kraków, Poland (Prof. Dr. Ewa Stepien), resulting 3 published articles and 1 chapter in book;
• 2010-2013 Laboratory of Atherothrombosis, Program of Cardiovascular Diseases, CIMA-University of Navarra, Navarra Institute for Health Research (IdiSNA), Pamplona, Spain (PhD Josune Orbe, PhD Carmen Roncal, PhD Jose A. Rodriguez, PhD Jose A. Paramo); Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Portugal (PhD Sérgio Dias, PhD Ana Costa) (Postdoctoral Fellowship: „Cristofor I. Simionescu”, Postdoctoral Fellowship Programme, ID POSDRU/89/1.5/S/55216), resulting 4 published articles;
• 2010 Paris-Cardiovascular Research Centre, Inserm U970, Paris, France (PharmD, PhD Chantal M. Boulanger), resulting 1 published article;
• 2009 Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Friederich Schiller University, Jena, Germany (PhD Frank D. Böhmer), resulting 1 published article;
• 2005-2008 Department of Physiology (Cell Physiology Research Group), University of Extremadura, Cáceres, Spain (PhD Juan A. Rosado, PhD Gines M. Salido) (Specific Support Action, PC6, SERA project, No. 016873), resulting 1 published article;
NATIONAL COLLABORATIONS
• 2023 “Prof. N.C. Paulescu” National Institute of Diabetes, Nutrition and Metabolic Diseases, Bucharest (Dr. Stefan Diana Simona, Dr. Guja Cristian), resulting 1 published article;
• 2018-2021 National Institute for Research and Development in the field of Pathology and Biomedical Sciences "Victor Babeş" Bucharest (INCDVB) (Dr. CSI. Mihaela Gherghiceanu);University of Medicine and Pharmacy "Carol Davila" Bucharest (UMFCD), (Prof. Dr. Dragoș Vinereanu); University and Emergency Hospital Bucharest, Cardiology Department, Bucharest, (Prof. Dr. Dragoș Vinereanu);Emergency Clinical Hospital "Pius Brînzeu" Timişoara- Research Center OncoGen (OncoGen) ( Prof. Dr. Virgil Păunescu) (Partnership PCCDI grant: BIOVEA) resulting 2 published articles and 2 chapters in books;
• 2018-2021 Fundeni Clinical Institute (Prof. Univ. Dr. Irinel Popescu, Dr. Simona O. Dima); University of Bucharest Faculty of Biology: Department of Anatomy, Physiology and Biophysics (Conf. Dr. Dana Cucu); University of Medicine and Pharmacy, Craiova (Prof. Dr. Adrian Săftoiu) (Partnership PCCDI grant: PANCNGS);
• 2013-2020 University of Bucharest, Faculty of Biology: Department of Anatomy, Physiology and Biophysics (Prof. Dr. Violeta Ristoiu), resulting 4 published articles;
• 2016-2020 University of Medicine and Pharmacy of Târgu Mureș, Clinical Department of Internal Medicine, (Dr. Dan Nistor); Emergency Clinical Hospital Floreasca, Bucharest, Internal Medicine Clinic (Dr. Sabina Frunza), (Competitiveness Operational Programme CDI grant, code SMIS: 104362, Contract no. 115/13.09.2016, THERAVALDIS), resulting 1 published article and 1 chapter in book;
• 2014-2016 Regina Maria Hospital, Ponderas Hospital: Bariatric Center of Excellence, Bucharest, (Dr. Cătălin Copăescu, Dr. Smeu Bogdan); “Prof. N.C. Paulescu” National Institute of Diabetes, Nutrition and Metabolic Diseases, Bucharest (Prof. Dr. Ionescu-Tîrgovişte Constantin, Dr. Guja Cristian, Dr. Stefan Diana Simona); ‘Carol Davila’ University of Medicine and Pharmacy, Bucharest (Dr. Iosif Liviu, Dr. Lixandru Daniela) (PCCA grant), resulting 3 published articles;
• 2017 Proestetica Medical Center, Bucharest, Romania (Dr. Dana Jianu), resulting 1 published article;
• 2008-2011 Internal Medicine Clinic, Emergency Clinical Hospital Floreasca, Bucharest (Prof. Dr. Daniela Bartos) Internal Medicine Clinic, Emergency Clinical Hospital Floreasca / ‘Carol Davila’ University of Medicine and Pharmacy /Colentina Clinical Hospital (Prof. Dr. Elisabeta Bãdilã) (Partnership PNCDI-2, CNMP grant), resulting 4 published articles;
• 2008-2011 CFR 2 University Hospital (Dr. Daniel Cochior and Dr. Aura Tudor) (PNCDI-2, Idei grant), resulting 3 published articles;
• 2006-2008 Elias University Emergency Hospital, Bucharest (Dr. Constantin Zamfir); University Emergency Hospital Bucharest (Dr. Adrian Badila); Medical Centrum, STS (Dr. Manuela Amuzescu)(Excellence Research Projects for young researchers grant) resulting 3 published articles;
• 2004-2007 “Dr. D. Gerota” Hospital, Bucharest (Dr. Adriana Sbarcea); Medical Centrum, STS/“Dr. D. Gerota” Hospital, Bucharest (Dr. Manuela Amuzescu) resulting 2 published articles;
• 2002-2005 Emergency Clinical Hospital Floreasca, Bucharest (Prof. Dr. Maria Dorobanţu);Emergency Clinical Hospital Floreasca/‘Carol Davila’ University of Medicine and Pharmacy /Colentina Clinical Hospital (Prof. Dr. Elisabeta Bãdilã); University of Bucharest, Faculty of Biology ((Prof. Florentina Pluteanu, Prof. Maria-Luisa Flonta) (VIASAN PNCDI grant), resulting 4 published articles;
• 2001-2002, 2004-2006 “Dr. D. Gerota” Hospital, Bucharest (Dr. Monica Capraru) (VIASAN PNCDI grants), resulting 1 published article;