Research  »  DEP
Medical and Pharmaceutical Bionanotechnologies

 

 

 

 

 

ABOUT

 

Cardiovascular diseases (CVD) are still the main widespread diseases that account for most deaths worldwide. According to statistics, in 2019, in the world, over 18.5 million people died from CVD. In the EU region, is also the leading cause of death, responsible for 4.2 million deaths a year close to half of all deaths. CVD is primarily caused by atherosclerosis (AS), a systemic disease characterized by lipid deposition in the artery walls with an associated, low-grade chronic inflammatory process.

We focus our research on developing advanced targeted therapies based on nanotechnology to mitigate the inflammatory process associated with cardiovascular diseases (CVD).

Research topics:

(i)             Nanotherapeutic strategies for cardiac fibrosis targeting the mechanisms underlying the fibroblast to myofibroblast transition;

(ii)           Development of biomimetic nanocarriers of pro-resolving mediators for inflammation resolution in atherosclerosis and cardiac fibrosis

(iii)          Endothelial- and monocyte/macrophages-targeted nanotherapies designed to reduce inflammation in experimental models of inflammation and atherosclerosis (nanoformulations for small pharmaceutical agents and siRNA/shRNA delivery);

(iv)          Investigation of cytotoxicity and intracellular response induced by nanomaterials in human cells.

 

 

 

 

 

 

RESEARCH TEAM

 

   

Dr. Habil. Manuela Calin

Senior scientist, Head of Department

manuela.calin@icbp.ro

CV-link

 

 

 

Dr. Daniela Rebleanu

Scientific Researcher grade III

daniela.rebleanu@icbp.ro

CV-link

 

 

 

Dr. Mihaela Georgiana Turtoi

Postdoctoral researcher, Scientific Researcher grade III

mihaela.turtoi@icbp.ro

CV-link

 

 

 

Dr. Cristina Ana Mocanu

Postdoctoral researcher, Scientific Researcher grade III

cristina.mocanu@icbp.ro

CV-link

 

 

 

Dr. Geanina Voicu

Postdoctoral researcher, Scientific Researcher grade III

geanina.voicu@icbp.ro

CV-link

 

 

 

Dr. Florentina Safciuc

Scientific Researcher

florentina.safciuc@icbp.ro

CV-link

 

 

 

Maria Anghelache

Ph.D. student, Scientific Researcher

anghelache.maria@icbp.ro

CV-link

 

 

 

Ruxandra Anton

Ph.D. student, Research Assistant

ruxandra.anton@icbp.ro

CV-link

 

 

 

Delia Boteanu

Ph.D. student, Research Assistant

delia.boteanu@icbp.ro

CV-link 

 

 

 

Marilena Misici

technician

 

 

 

 

PUBLICATIONS

 

List of Published Papers in the last ten years (ISI journals with impact factor)

 

 

2024 

  1. Anghelache M,Voicu G, Deleanu M, Turtoi M, Safciuc F, Anton R, Boteanu D, Fenyo IM, Manduteanu I, Simionescu M, Calin M, Biomimetic Nanocarriers of Pro-Resolving Lipid Mediators for Resolution of Inflammation in Atherosclerosis, Adv Healthc Mater, 2024 Jan;13(3):e2302238. doi: 10.1002/adhm.202302238. IF: 11.092
  2. Brebu M, Pamfil D, Stoica I, Aflori M, Voicu G, Stoleru E. Photo-crosslinked chitosan-gelatin xerogel-like coating onto "cold" plasma functionalized poly(lactic acid) film as cell culture support. Carbohydr Polym. 2024 Sep 1;339: 122288. doi: 10.1016/j.carbpol.2024.122288. Epub 2024 May 17, IF: 11.2.

 

2023 

  1. Varna, M.*; Calin, M.*; Gebeshuber, I.C.*, Advances in Natural and Bio-Inspired Nanoparticles for the Treatment of Cardiovascular Diseases. Nanomaterials 2023, 13, 3015.https://doi.org/10.3390/nano13233015 IF: 5.719
  2. Pelin IM, Popescu I, Calin M, Rebleanu D, Voicu G, Ionita D, Zaharia MM, Constantin M, Fundueanu G. Tri-Component Hydrogel as Template for Nanocrystalline Hydroxyapatite Deposition Using Alternate Soaking Method for Bone Tissue Engineering Applications. Gels. 2023 Nov 16;9(11):905. doi: 10.3390/gels9110905. IF: 4.6
  3. Voicu G, Cristina Ana Mocanu, Florentina Safciuc, Maria Anghelache, Mariana Deleanu, Sergiu Cecoltan, Mariana Pinteala, Cristina Mariana Uritu, Ionel Droc, Maya Simionescu, Ileana Manduteanu, Calin M, Nanocarriers of shRNA-Runx2 directed to collagen IV as a nanotherapeutic system to target calcific aortic valve disease, Materials Today Bio, 100620, 2023, IF: 10.761
  4. Craciun BF, Clima L, Bostiog DI, Silion M, Calin M, Peptanariu D, Pinteala M, Multilayer gold nanoparticles as non-viral vectors for targeting MCF - 7 cancer cells, Biomaterials Advances, 2023, 144, 213201, IF 8.457

 

 

2022 

  1. Movileanu C, Anghelache M, Turtoi M, Voicu G, Neacsu IA, Ficai D, Trusca R, Oprea O, Ficai A, Andronescu E, Calin M. Folic acid-decorated PEGylated magnetite nanoparticles as efficient drug carriers to tumor cells overexpressing folic acid receptor, Int J Pharm. 2022 Aug 8;625:122064. doi: 10.1016/j.ijpharm.2022.122064, IF 6.510
  2. Turtoi, M.; Anghelache, M.; Patrascu, A.A.; Deleanu, M.; Voicu, G.; Raduca, M.; Safciuc, F.; Manduteanu, I.; Calin, M.; Popescu, D.-L. Antitumor Properties of a New Macrocyclic Tetranuclear Oxidovanadium(V) Complex with 3-Methoxysalicylidenvaline Ligand. Biomedicines 2022, 10, 1217. https://doi.org/10.3390/biomedicines10061217, IF 6.081
  3. Fundueanu, G.; Constantin, M.; Turtoi, M.; Bucatariu, S.-M.; Cosman, B.; Anghelache, M.; Voicu, G.; Calin, M. Bio-Responsive Carriers for Controlled Delivery of Doxorubicin to Cancer Cells. Pharmaceutics 2022, 14, 865. https://doi.org/10.3390/pharmaceutics14040865, IF 6.525
  4. Voicu, G.; Rebleanu, D.; Mocanu, C.A.; Tanko, G.; Droc, I.; Uritu, C.M.; Pinteala, M.; Manduteanu, I.; Simionescu, M.; Calin, M. VCAM-1 Targeted Lipopolyplexes as Vehicles for Efficient Delivery of shRNA-Runx2 to Osteoblast-Differentiated Valvular Interstitial Cells; Implications in Calcific Valve Disease Treatment. Int. J. Mol. Sci. 2022, 23, 3824. https://doi.org/10.3390/ijms23073824. IF 6.208
  5. Zaltariov M, Turtoi M, Peptanariu D, Macsim AM, Clima L, Cojocariu C, Vornicu N, Ciubotaru BI, Bargan A, Calin M, Cazacu M, Chemical Attachment of 5-Nitrosalicylaldimine Motif to Silatrane Resulting in an Organic-Inorganic Structure with High Medicinal Significance, Pharmaceutics 2022, 14(12), 2838; https://doi.org/10.3390/pharmaceutics14122838, IF 6.525

 

2021 

  1. Popescu I, Lupei M, Constantin M, Voicu G, Calin M, Prisacaru AI, Fundueanu G, Double cross-linked pectin beads stable in physiological environment as potential support for biomedical applications, Journal of Polymer Research volume 28, Article number: 424 (2021) IF 3.097
  2. Mocanu CA, Fuior EV, Voicu G, Rebleanu D, Safciuc F, Deleanu M, Fenyo IM, Virginie Escriou V, Manduteanu I, Simionescu M, Calin M, P-selectin targeted RAGE-shRNA lipoplexes alleviate atherosclerosis-associated inflammation, J Control Rel, 2021, 338: pp. 754–772. https://doi.org/10.1016/j.jconrel.2021.09.012, IF 11.467
  3. Anghelache M, Turtoi M, Petrovici AR, Fifere A, Pinteala M,Calin M, Development of Dextran-Coated Magnetic Nanoparticles Loaded with Protocatechuic Acid for Vascular Inflammation Therapy, Pharmaceutics 2021, 13, 1414. https://doi.org/10.3390/pharmaceutics13091414, IF 6,525
  4. Popescu I, Lupei M, Constantin M, Voicu G, Calin M, Prisacaru AI, Fundueanu G, Double cross-linked pectin beads stable in physiological environment as potential support for biomedical applications, J Polymer Res. 2021, IF 3,097
  5. Turtoi M, Anghelache M, Bucatariu SM, Deleanu M, Voicu G, Safciuc F, Manduteanu I, Fundueanu G, Simionescu M, Calin M*, A novel platform for drug testing: Biomimetic three-dimensional hyaluronic acid-based scaffold seeded with human hepatocarcinoma cells. Int J Biol Macromol. 2021; 185:604-619. doi: 10.1016/j.ijbiomac.2021.06.174. IF 6,953
  6. Turtoi M, Anghelache M, Patrascu AA, Maxim C, Manduteanu I, Calin M, Popescu DL, Synthesis, Characterization, and In Vitro Insulin-Mimetic Activity Evaluation of Valine Schiff Base Coordination Compounds of Oxidovanadium(V). Biomedicines. 2021 May 17;9(5):562. doi: 10.3390/biomedicines9050562. IF 6,081
  7. Manea SA, Vlad ML, Rebleanu D, Lazar AG, Fenyo IM, Calin M, Simionescu M, Manea A, Detection of Vascular Reactive Oxygen Species in Experimental Atherosclerosis by High-Resolution Near-Infrared Fluorescence Imaging Using VCAM-1-Targeted Liposomes Entrapping a Fluorogenic Redox-Sensitive Probe., Oxid Med Cell Longev. 2021 Mar 9;2021: 6685612. doi: 10.1155/2021/6685612. IF 7.310
  8. Popescu I, Turtoi M, Suflet DM, Dinu MV, Darie-Nita RN, Anghelache M, Calin M, Constantin M, Alginate/poloxamer hydrogel obtained by thiol-acrylate photopolymerization for the alleviation of the inflammatory response of human keratinocytes, Int J Biol Macromol. 2021 Mar 16;180: 418-431. doi: 10.1016/j.ijbiomac.2021.03.082 IF 8.025

 

2020 

  1. Bucatariu S., Constantin M., Varganici C.D., Rusu D., Nicolescu A., Prisacaru I., Carnuta M., Anghelache M., Calin M., Ascenzi P., Fundueanu G. A new sponge-type hydrogel based on hyaluronic acid and poly(methylvinylether-alt-maleic acid) as a 3D platform for tumor cell growth, Int J Biol Macromol. 2020, 165: 2528–2540. IF 6.78
  2. Fuior E.V.; Mocanu C.A.; Deleanu M.; Voicu G.; Anghelache M.; Rebleanu D.; Simionescu M.; Calin M*. Evaluation of VCAM-1 Targeted Naringenin/Indocyanine Green-Loaded Lipid Nanoemulsions as Theranostic Nanoplatforms in Inflammation. Pharmaceutics 2020, 12, 1066. https://doi.org/10.3390/pharmaceutics12111066. IF 6.321
  3. Voicu G, Rebleanu D, Constantinescu CA, Fuior EV, Ciortan L, Droc I, Uritu CM, Pinteala M, Manduteanu I, Simionescu M, Calin M*, Nano-Polyplexes Mediated Transfection of Runx2-shRNA Mitigates the Osteodifferentiation of Human Valvular Interstitial Cells. Pharmaceutics. 2020 Jun 2;12(6):E507. doi: 10.3390/pharmaceutics12060507 IF 6.321
  4. Constantin M, Bucatariu S, …, Anghelache M, Fundueanu G, Pullulan derivative with cationic and hydrophobic moieties as an appropriate macromolecule in the synthesis of nanoparticles for drug delivery, International Journal of Biological Macromolecules, 2020, 164, pp. 4487–4498, https://doi.org/10.1016/j.ijbiomac.2020.09.064, IF 8.025

 

2019 

  1. Fuior EV, Deleanu M, Constantinescu CA, Rebleanu D, Voicu G, Simionescu M, Calin M*, Functional Role of VCAM-1 Targeted Flavonoid-Loaded Lipid Nanoemulsions in Reducing Endothelium Inflammation, Pharmaceutics. 2019 Aug 3;11(8). pii: E391. doi: 10.3390/pharmaceutics11080391. IF 6.321
  2. Rebleanu D, Gaidau C, Voicu G, Constantinescu CA, Mansilla Sánchez C, Rojas TC, Carvalho S, Calin M*. The impact of photocatalytic Ag/TiO2 and Ag/N-TiO2 nanoparticles on human keratinocytes and epithelial lung cells. Toxicology. 2019 Jan 31. pii: S0300-483X(18)30225-7. doi: 10.1016/j.tox.2019.01.013.  IF 4.571
  3. Constantinescu CA, Fuior EV, Rebleanu D, Deleanu M, Simion V, Voicu G, Escriou V, Manduteanu I, Simionescu M, Calin M*. Targeted Transfection Using PEGylated Cationic Liposomes Directed Towards P-Selectin Increases siRNA Delivery into Activated Endothelial Cells. Pharmaceutics. 2019 Jan 21;11(1). pii: E47. doi:10.3390/pharmaceutics11010047. IF 4.473

 

2018 

  1. David G, Clima L, Calin M, Constantinescu CA, Balan-Porcarasu M, Uritu CM, Simionescu BC, Squalene/polyethylenimine based non-viral vectors: Synthesis and use in systems for sustained gene release, Polymer Chemistry, 9 1072-1081, 2018  IF 4.790 
  2. Tucureanu MM, Rebleanu D, Constantinescu CA, Deleanu M, Voicu G, Butoi E, Calin M, Ileana Manduteanu, Lipopolysaccharide-induced inflammation in monocytes/macrophages is blocked by liposomal delivery of Gi-protein inhibitor, Int J Nanomedicine. 2018;13:63-76. IF 4.6

 

2017 

  1. A. I. Dascalu, R. Ardeleanu, A. Neamtu, S. S. Maier, C. M. Uritu, A. Nicolescu, M. Silion, D. Peptanariu, M. Calin, M. Pinteala,Transfection-capable polycationic nanovectors which include PEGylated-cyclodextrin structural units: a new synthesis pathway, J. Mater. Chem. B, 2017,5, 7164-7174; DOI:10.1039/C7TB01722G
  2. Simionescu BC, Drobota M, Timpu D, Vasiliu T, Constantinescu CA, Rebleanu D, Calin M, David G*, Biopolymers/poly(ε-caprolactone)/polyethylenimine functionalized nano-hydroxyapatite hybrid cryogel: Synthesis, characterization and application in gene delivery, Materials Science and Engineering: C (2017), 81: 167-176.
  3. Calin M, Manduteanu I, Emerging Nanocarriers-Based Approaches To Diagnose And Reduce Vascular Inflammation In Atherosclerosis, Current Medicinal Chemistry 2017;24(6):550-567.

 

2016 

  1. Simion V, Constantinescu CA, Stan D, Deleanu M, Tucureanu MM, Butoi E, Manduteanu I, Simionescu M, Calin M, P-Selectin Targeted Dexamethasone-Loaded Lipid Nanoemulsions: A Novel Therapy to Reduce Vascular Inflammation, Mediators Inflamm. 2016; 2016:1625149. Epub 2016 Sep 14.
  2. Tucureanu MM, Butoi E, Gan AM, Daniela Stan, Constantinescu CA, Calin M, Simionescu M, Manduteanu I, Amendment of the cytokine profile in macrophages after their interaction with smooth muscle cells: Differential modulation by fractalkine and resistin, Cytokine, 2016, 83: 250–261,
  3. Butoi E, Gan AM, Tucureanu MM, Stan D, Macarie RD, Constantinescu C, Calin M, Simionescu M, Manduteanu I, Cross-talk between macrophages and smooth muscle cells impairs collagen and metalloprotease synthesis and promotes angiogenesis, Biochim Biophys Acta. 2016 Apr 7; 1863(7 Pt A):1568-1578. doi: 10.1016/j.bbamcr.2016.04.001
  4. Simion V, Stan D, Constantinescu C A, Deleanu M, Dragan E, Tucureanu MM, Gan AM, Butoi E, Constantin A, Manduteanu I, Simionescu M, Calin M, Conjugation of curcumin-loaded lipid nanoemulsions with cell-penetrating peptides increases their cellular uptake and enhances the anti-inflammatory effects in endothelial cells. J Pharm Pharmacol. 2016 Feb;68(2):195-207

 

2015 

  1. Roblek M, Calin M, Schlesinger M, Stan D, Zeisig R, Simionescu M, Bendas G, Borsig L,Targeted delivery of CCR2 antagonist to activated pulmonary endothelium prevents metastasis, J Control Release. 2015 Oct 30;220(Pt A):341-347. doi: 10.1016/j.jconrel.2015.10.055.
  2. Marin L,  Ailincai D,  CalinM, Stan D, Constantinescu CA,  Ursu L, DorofteiF,  PintealaM,  SimionescuBC, Barboiu M, Dynameric Frameworks for DNA transfection, ACS Biomater. Sci. Eng., 2016, 2 (1), pp 104–111,  DOI: 10.1021/acsbiomaterials.5b00423
  3. Uritu CM, Calin M, Maier SS, Cojocaru C, Nicolescu A, Peptanariu D, Constantinescu CA, Stan D, Barboiu M, Pinteala M, Flexible cyclic siloxane core enhances the transfection efficiency of polyethylenimine-based non-viral gene vectors, J. Mater. Chem. B, J. Mater. Chem. B, 2015, 3: 8250-8267, DOI:10.1039/c5tb01342a.
  4. Schlesinger M, Zeisig R, Ortmann K, Calin M, Gerber U, Roblek M, Borsig L, Bendas G, Inhibition of chemokine receptor CCR2 reduces sarcoma cell transendothelial migration and metastasis to the lungs, Int J Clin Pharmacol Ther. 2015 Dec;53(12):1046-1048.DOI: 0.5414/CPXCES14EA04
  5. Uritu CM, Varganici C., Ursu L, Coroaba A, Nicolescu A, Dascalu AI, Peptanariu D, Stan D,. Constantinescu CA, Simion V, Calin M, Maier SS, Pinteala M, Barboiu M, Hybrid Fullerene Conjugates as Vectors for DNA Cell-Delivery, J. Mater. Chem. B. 3 (2015) 2433-2446
  6. Calin M*, Stan D, Schlesinger M, Simion V, Deleanu M, Ana Constantinescu C, Gan AM, Pirvulescu MM, Butoi E, Manduteanu I, Bota M, Enachescu M, Borsig L, Bendas G, Simionescu M, VCAM-1 directed target-sensitive liposomes carrying CCR2 antagonists bind to activated endothelium and reduce adhesion and transmigration of monocytes, Eur J Pharm Biopharm. 89 (2015) 18-29. doi: 10.1016/j.ejpb.2014.11.016

 

2014 

  1. Gan AM, Butoi E, Manea A, Pirvulescu MM, Stan D, Simion V, Calin M, Simionescu M, Manduteanu I., Functional analysis of the fractalkine gene promoter in human aortic smooth muscle cells exposed to proinflammatory conditions, FEBS J.( 2014) 281(17):3869-81
  2. Pirvulescu MM, Gan AM, Stan D, Simion V, Calin M, Butoi E, Manduteanu I, Subendothelial resistin enhances monocyte transmigration in a co-culture of human endothelial and smooth muscle cells by mechanisms involving fractalkine, MCP-1 and activation of TLR4 and Gi/o proteins signaling, Int J Biochem Cell Biol. (2014) 50:29-37. doi: 10.1016/j.biocel.2014.01.022.
  3. Durdureanu-Angheluta A, Uritu CM, Coroaba A, Minea B, Doroftei F, Calin M, Maier SS, Pinteala M, Simionescu M, Simionescu BC, Heparin-Anthranoid Conjugates Associated with Nanomagnetite Particles and Their Cytotoxic Effect on Cancer Cells, J. Biomed. Nanotechnol. 10, 131-142 (2014), doi:10.1166/jbn.2013.1690

 

2013

  1. Simion V, Daniela Stan D, Gan AM, Pirvulescu MM, Butoi E, Manduteanu I, Deleanu M, Andrei E, Durdureanu-Angheluta AM, Bota M, Enachescu M, Calin M*, Simionescu M, Development of curcumin-loaded poly(hydroxybutyrate-co-hydroxyvalerate) nanoparticles as anti-inflammatory carriers to human activated endothelial cells, Journal of Nanoparticle Research, 15 (12), 1-15 (2013),  DOI: 10.1007/s11051-013-2108-1
  2. Calin M, Stan D, Simion V, Stem Cell Regenerative Potential Combined With Nanotechnology And Tissue Engineering For Myocardial Regeneration, Curr Stem Cell Res Ther. 2013 Jul 1;8(4):292-303.
  3.  Gan AM, Pirvulescu MM, Stan D, Simion V, Calin M, Manduteanu I, Butoi E, Cross-talk between activated monocytes and smooth muscle cells activates the STAT3 pathway and induces resistin and reactive oxygen species production, J Cell Biochem. 2013 Apr 19. doi: 10.1002/jcb.24571.
  4.  A.M. Gan, E. Butoi, A. Manea, V. Simion, D. Stan, M.M. Parvulescu, M. Calin, I. Manduteanu, M. Simionescu, Inflammatory effects of resistin on human smooth muscle cells: up-regulation of fractalkine/CX3CR1 expression by TLR4 and Gi-protein pathways, Cell and Tissue Research (2013), 351(1):161-174.

 

 

List of Book Chapters

 

 

  1. Fuior EV, Calin M (2020), Nanoparticle-based delivery of polyphenols for the treatment of inflammation-associated diseases. In Book: Advances and Avenues in development of novel carriers for Bioactives and biological agents, Editors: Manju Rawat Singh, Deependra Singh, Jagat Kanwar, Nagendra Singh Chauhan, 343-382, Academic Press, ELSEVIER, ISBN: 978-0-12-819666-3. Total Number of Matches displayed (Single Matches excluded): 90
  2. Calin M, Butoi E, Manea SA, Simionescu M, Manea A (2016). Lessons from experimental-induced atherosclerosis – valuable for the precision medicine of tomorrow. In book: Arterial Revascularization of the Head and Neck: Text Atlas for Prevention and Management of Stroke, pp.341-365, Editor Horia Muresian, SPRINGER, New York, DOI: 10.1007/978-3-319-34193-4_17, ISBN-10: 331934191X, ISBN-13: 978-3319341910 (Total Number 10 according Karlsruhe Virtual Catalogue). Total Number of Matches displayed (Single Matches excluded): 71
  3. Calin, M. (2012) Immunoliposomes for Specific Drug Delivery, in Antibody-Mediated Drug Delivery Systems: Concepts, Technology, and Applications (editors Y. Pathak and S. Benita), 229-266, JOHN WILEY & SONS, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118229019.ch12 (Total Number 53/2020 according Karlsruhe Virtual Catalogue).

 

 

List of Patents:

  1. European Patent no. EP2832373, inventors Bendas G, Borsig L, Calin M, Cevher E, Enachescu M, Gok MK, Hoffmann A, Mihaly M, Pabuccuoglu SK, Simionescu M, Schlesinger M, Zeisig R: "Liposome for blocking site-specifically chemokine-related inflammatory processes in vascular diseases and metastasis"
  2. European Patent: application no: 17464014.4-1102, inventors: Gaidau C, Calin M, Constantinescu CA, Rebleanu D, Stoica T: “Leather with anti-microbial and self-cleaning properties and process for obtaining therof”
  3. OSIM, application no. A/00966, inventors: Gaidau C, Calin M, Constantinescu CA, Rebleanu D, Stoica : “Leather with anti-microbial and self-cleaning properties and process for obtaining therof”
  4. OSIM application no A/00811, inventors Calin M, Rebleanu D, Constantinescu CA, Voicu G, Deleanu M, Manduteanu I: "Process for obtaining the nanocarriers for targeted delivery of interference ribonucleic acid (RNA) to aortic valve cells”
  5. OSIM application no A/01055, inventors: Ficai D, Ardelelean I, Ilie C, Calin M, Fuior EV, Fifere A, Pinteala M, Fundueanu-Constantin G, Ficai A, Simionescu M, Andronescu E: "Vertical magnetic (electro) separator of isomagnetic nanoparticles”
  6. OSIM application no.  A/00388/ 20.07.2023, inventors: Movileanu C, Ficai D, Ficai A, Calin M, Anghelache M, Gafencu A, Fundueanu-Constantin G, Pinteala M, Simionescu M, Andronescu E, „ Intelligent nanosystems for cellular vectorization of bioactive compounds”.

 

GRANTS

 

 

List of awarded research projects in the last ten years

   

  1. 2023-2026: PNRR-III-C9-2022-I8, CF93/2022 ctr. 760063/2023 “New nanotherapeutic strategies for cardiac fibrosis targeting the mechanisms underlying the fibroblast to myofibroblast transition”, project director Rostyslav Bilyy https://heartcure.eu/?i=1
  2. 2021-2023: PNCDI IV Grant nr. PN-III-P4-ID-PCE-2020-2465: “Targeted therapy based on biomimetic nanocarriers for resolution of inflammation in atherosclerosis” http://www.icbp.ro/static/en/en-networking_grants-grants-national_grants/nanores.html
  3. 2018-2022: PCCF project, cod PN-III-P4-ID-PCCF-2016-0050 (5D-nanoP), “Mimicking living matter mechanisms by five-dimensional chemistry approaches" partners: Institute of Macromolecular Chemistry “Petru Poni, Iasi; IBPC “N. Simionescu”, Bucharest; Center for Organic Chemistry "Costin D. Neniţescu", Bucharest http://www.intelcentru.ro/5D-nanoP/
  4. 2020-2022: PD project, PN-III-P1-1.1-PD-2019-0247, Preclinical evaluation of newly designed vanadium compounds for diabetes therapy (Mihaela Turtoi), http://www.icbp.ro/static/en/en-networking_grants-grants-national_grants/diavan.html
  5. 2018-2020: PCCDI Complex Project nr. 13 PCCDI/2018 (INTERA) "Intelligent therapies for non-communicable diseases based on controlled release of pharmacological compounds from encapsulated engineered cells and targeted bio-nanoparticles"; INTERA3 component project:” Intelligent nano-bioparticles designed to function as vectors for targeted delivery of bioactive compounds in vascular inflammation therapy” http://www.icbp.ro/static/en/en-networking_grants-grants-national_grants/intera.html 
  6. 2017-2018: PN-III-P2-2.1-PED-2016-1308, Nanotechnology-based method for non-invasive molecular imaging of oxidative stress in cardiovascular disorders, http://www.icbp.ro/static/en/en-networking_grants-grants-national_grants/echoes.html
  7. 2016-2020: POC-E, A1.1.4 Attracting personnel with advanced skills from abroad for capacity building “Targeted therapies for aortic valve disease in diabetes”, http://theravaldis.icbp.ro/ 
  8. 2015-2018: SIINN ERA-NET project FP7 scheme (NANO_SAFE_LEATHER): “The effect on human health of Ag/TiO2 NM-treated leathers for footwear industry”, partners: The Institute for Research and Development of Textiles and Leather, Romania; ICBP "Nicolae Simionescu", Romania; University of Minho, Portugal; Montana University of Leoben, Austria; SC TARO COMMIMPEX LTD, Romania. http://www.nanosafeleather.eu
  9. 2015-2017: PNCDI II Grant nr. PN-II-RU-TE-2014-4-1837: "Endothelium-targeted Nanotherapies designed to silence receptor for advanced glycation products (RAGE) in atherosclerosis" http://www.icbp.ro/static/en/en-networking_grants-grants-national_grants/nanorage.html
  10. 2011-2016: PCCE project PNII-ID-PCCE-2011-2-0028, "Biologically inspired systems for engineered structural and functional entities", http://www.intelcentru.ro/Biomimetics_PCCE
  11. 2011-2016: PN-II-ID-PCE-2011-3-0928, "Molecular mechanisms involved in cytokine- and chemokine-dependent vascular inflammation usable as targets for nanotherapeutic strategies", http://www.icbp.ro/static/en/en-networking_grants-grants-national_grants/refinater.html
  12. 2011-2014: EuroNanoMed ERA-NET project FP7 scheme (NANODIATER), ctr. 4_001/2011 “Nanoparticles designed to target chemokine-related inflammatory processes in vascular diseases and cancer metastasis and implementation of a biosensor to diagnose these disorders”, partners: ICBP "Nicolae Simionescu", Romania; Center of Surface Science and Nanotechnology, University Polytechnic of Bucharest; University of Bonn, Germany; Istanbul University, Turkey; University of Zürich, Switzerland; EPO Berlin GmbH, Germany; SC Optoelectronica 2000 SRL http://test.icbp.ro/resources/static_files/Grants/nanodiater