Research
Research
Achievements & Original concepts/ Realizari & Concepte originale
ORIGINAL CONCEPTS AND SELECTED FINDINGS/ CONCEPTE ORIGINALE SI SELECTIE A DESCOPERIRILOR
- Transcytosis of molecules and its mechanisms: fluid phase, adsorptive and receptor mediated;
- Histamine receptors are expressed preferentially on venular endothelial cells (EC);
- Hyperglycemia induced - increased atherogenicity of lipoproteins contribute to accelerated atherosclerosis in diabetes;
- Albumin binding proteins are expressed by endothelial cells and cardiomyocytes;
- The initial event in atherogenesis is the accumulation of modified lipoproteins within the subendothelial space of the aorta, cardiac valves, coronary arteries of humans and experimental animals;
- Endothelial cell response to normal and abnormal stimuli;
- Inhibition of atheroma formation is potentiated by the association of ACE26 inhibitors with calcium channel blockers;
- Identification of FcRn in human placental endothelial cells;
- Detection of new Fc-receptor on placental endothelial cell;
- Detection of new antigens in activated EC by high resolution 2-D gel electrophoresis;
- Polymorphism of candidate gene (eNOS, ACE) is associated with endothelial dysfunction in atherosclerosis and diabetes;
- In experimental hyperlipemia-hyperglycemia administration of L-arginine improves the microangiopathic changes of coronaries and enhances vasodilation of resistance arteries;
- High uptake of folic acid by activated macrophages in experimental hyperlipidemia;
- Circulating microparticles contribute to human peripheral venular dysfunction;
- Calcium channel blockers (felodipine, amlodipine) and ACE inhibitor (enalapril maleat) regulate NADPH oxidase in pericytes;
- Nifedipine has deleterious effects on calcium homeostasis and aggravates atheroma formation;
- Clotrimazole has comparable properties with calcium antagonists;
- Enoxaparin restores the vascular reactivity of resistance arteries in ageing and diabetes;
- Enoxaparin reduces monocyte adhesion to TNF-, LPS-, or high glucose-activated EC;
- Superoxide dismutase entrapped-liposomes restore the impaired endothelium-dependent relaxation of resistance arteries in experimental diabetes;
- VCAM-1 is an appropriate target for specific delivery of drugs to activated EC by immunoliposomes;
- Aspirin corrects the high glucose-induced changes in intracellular calcium homeostasis and NO production in human EC;
- Simvastatin inhibits transcytosis of LDL in hyperlipemia reducing plaque progression;
- Simvastatin and Amlodipin increase the sera antioxidant potential in patients with stable angina;
- Atorvastatin downregulates NADPH oxidase activity, and decreases NOX1 and p22phox gene expression in human aortic smooth muscle cells exposed to glycated LDL;
- Enoxaparin reduces endothelial cell activation;
- PPARα activators (fenofibrate and clofibrate) inhibit MCP-1 and fractalkine expression induced by high glucose in human smooth muscle cells;
- PPAR agonists decrease plaque vulnerability through modulation of MMP-2 activity;
- Anti-oxidant potential of felodipine is higher that that of amlodipine;
- Nebivolol has a reversible vasodilator effect on renal arteries.
ORIGINAL ANIMAL MODELS
The hyperlipemic hamster
The hyperglycemic / hyperlipemic hamster
The insulin-resistant hamster
L-NAME-induced hypertensive hamster
Hypertensive/hyperlipemic hamster
NEW CELL LINES
Existent in the Cell Culture Core Facility
ADVANCED BIOMEDICAL TRAINING
- Ph.D. program in cellular and molecular biology
- Postdoctoral training of scientists from Romania and abroad
- National and International Congresses of the Romanian Society for Cell Biology
- Annual Advanced Study School "From Cell and Molecular Biology to the Medicine of 21st Century", under auspices of the Romanian Academy.
CONCEPTE ORIGINALE SI SELECTIE A DESCOPERIRILOR
- Transcitoza moleculelor si mecanismele ei: faza fluida, adsorbtiva, mediata de receptor;
- Receptorii la histamina sunt exprimati preferential pe celulele endoteliale venulare (EC);
- Aterogenicitatea crescuta a lipoproteinelor, indusa de hiperglicemie, contribuie la accelerarea aterosclerozei in diabet
- Proteinele de legare a albuminei sunt exprimate de celulele endoteliale si cardiomiocite;
- Evenimentul initial in aterogeneza este acumularea de lipoproteine modificate in spatiul subendotelial al aortei, valvelor cardiace, arterelor coronare ale omului si animalelor de experienta;
- Raspunsul celulei endoteliale la stimuli normali si anormali;
- Inhibarea formarii ateromului este potentata de asocierea inhibitorilor ACE26 cu blocantii de canale de calciu;
- Identificarea FcRn in celulele endoteliale placentare umane;
- Detectarea de noi receptori Fc pe celulele endoteliale placentare;
- Detectarea de noi antigeni in CE activate prin electroforeza bidimensionala in gel;
- Polimorfismul genelor candidate (eNOS, ACE) este este asociat cu disfunctia endoteliala in ateroscleroza si diabet;
- In hiperlipemia-hiperglicemia experimentala administrarea de L-arginina imbunatateste modificarile microangiopatice ale coronarelor si creste vasodilatatia arterelor de rezistenta;
- Preluarea crescuta de acid folic de catre macrofagele activate in hiperlipidemia experimentala;
- Particulele microcirculante contribuie la disfunctia venulara periferica umana;
- Blocantii de canale de calciu (felodipina, amlodipine) si inhibitorii ACE (enalapril maleat) regleaza NADPH oxidaza in pericite;
- Nifedipina are efecte deletorii asupra homeostaziei calciului si agraveaza formarea ateromului;
- Clotrimazolul are proprietati comparabile cu antagonistii de calciu;
- Enoxaparina reface reactivitatea vasculara a arterelor de rezistenta in imbatranire si diabet;
- Enoxaparina reduce aderarea monocitelor la endoteliul activat de TNF, LPSsau glucoza;
- Superoxid dismutaza trapata in liposomi restabileste relaxarea dependenta de endoteliu a arterelor de rezistenta in diabetul experimental;
- VCAM-1 este o tinta potrivita pentru furnizarea de medicamente prin intermediul liposomilor catre endoteliu activat;
- Aspirina corecteaza modificarile induse de glucoza in homeostazia calciului intracellular si productia de NO in endoteliul uman;
- Simvastatin inhiba transcitoza LDL in hiperlipemie, reducand progresia placii;
- Simvastatin si Amlodipin cresc potentialul antioxidant seric la pacientii cu angina stabila;
- Atorvastatin scade activitatea NADPH oxidazeisi descreste expresia genica a NOX1 si p22phox in celulele musculare netede de arc aortic expuse la LDL glicat;
- Enoxaparina reduce activarea celulei endoteliale;
- Activatorii de PPARα (fenofibrat si clofibrat) inhiba expresia MCP-1 si fractalkinei indusa de glucoza ridicata in celulele musculare netede umane;
- Agonistii PPAR descresc vulnerabilitatea placii prin modularea activitatii MMP-2;
- Potentialul antioxidant al felodipinei este mai mare decat cel al amlodipinei;
- Nebivolol are un efect vasodilatator reversibil pe arterele renale.
MODELE ANIMALE ORIGINALE
Hamsterul hiperlipemic
Hamsterul hiperglicemic/ hiperlipemic
Hamsterul rezistent la insulina
Hamsterul cu hipertensiune indusa de L-NAME
Hamsterul hipertensiv/ hiperlipemic
NOI LINII CELULARE
Existente in Laboratorul central de culturi celulare
PREGATIRE BIOMEDICALA AVANSATA
- Program doctoral in biologia celulara si moleculara
- Pregatire postdoctorala a cercetatorilor din tara si din strainatate
- Congrese nationale si international ale Societatii Romane de Biologie Celulara
- Scoala de studii avansate anuala “De la biologia celulara si moleculara la medicina secolului 21”, sub auspiciile Academiei Romane.