International
Comprehensive and personalized assessment of acute coronary syndrome by multiomic approach and artificial intelligence strategy
The CardioSCOPE project aims to bring together experts from Companies and Αcademia throughout Europe to exchange and expand their expertise on interdisciplinary approaches, to enhance the Research and Innovation capacity of Europe in the field of cardiovascular diseases.
Connecting and expanding Europe-wide biobanks and expertise through a comprehensive multiomics approach for the discovery of novel pathological players, CardioSCOPE will give deeper insights into acute coronary syndrome (ACS) development and progression towards major adverse cardiovascular events (MACE). We will use well-defined prospective cohorts to discover and validate novel genomic, transcriptomic, proteomic and metabolomic signatures specific for ACS and MACE, to be combined in multimarker models by machine learning/artificial intelligence algorithms, enabling more accurate ACS diagnosis and MACE prediction. This excellent research network aims at building scientists competent for the upcoming “omics” era by training and knowledge transfer. Specific research skills not available at home institutions will be acquired through individually designed secondment plans, training schools, webinars and short-term courses. Intersectoral activities will improve entrepreneurial skills of consortium staff and facilitate transformation of scientific breakthroughs into commercially available products/services. CardioSCOPE includes experts with a wide clinical and research experience, access to patients with ACS and the expertise required for achieving set goals. World-class institutions gathered within this consortium (from 6 countries: 7 academic, 4 companies, 1 hospital) offer specific expertise, state-of-the-art equipment and adequate human resources to address these challenges. In summary, the results of this project will transcend our own scientific interests to enable a transfer of knowledge into a multidisciplinary environment and achieving significant impact on ACS management and policies in Europe.
Objectives
- O1: To discover novel pathological players for ACS and MACE by applying systems biology approach and multiomics analysis.
- O2: To develop multimarker models for better diagnosis of ACS and prognosis of MACE by applying data integration through machine learning (ML) and artificial intelligence (AI) approaches.
- O3: To validate developed multimarker models on independent cohorts.
- O4: To develop standard operative procedures (SOP) for measuring and evaluating ACS markers using wetlab and dry lab working protocols.
- O5: To build scientists competent for using omics technologies in everyday clinical practice.
- O6: To disseminate the ideas and goals behind the CardioSCOPE.
WORK PACKAGES
TEAM
Kickoff meeting
ICBP TEAM REPORTS
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ANCA GAFENCU, PhD |
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IRINA TUDORACHE, PhD student |
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GABRIELA CIUMEICA, PhD student |
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RAZVAN MACARIE, PhD |
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RADU IONITA, PhD |
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