National Grants
RO
GRANT acordat de Autoritatea Naționala pentru Cercetare Stiintifica si Inovare, CNCS-UEFISCDI TIP PROIECT: Proiect experimental demonstrativ (PED) COD PROIECT: PN-IV-P7-7.1-PED-2024-1446 CONTRACT: 93/2025 TITLU PROIECT: Substituenti inovativi cu structura tridimensionala si activitate antimicrobiana pe baza de colagen pentru reconstructia cranio-faciala ACRONIM: INNACOLL PERIOADA: 6.05.2025-6.05.2027 (24 luni) BUGET: 746.162 LEI COORDONATOR: Institutul de Biologie și Patologie Celulară „Nicolae Simionescu“ (IBPC-NS) DIRECTOR DE PROIECT: Dr. Irina Titorencu ECHIPA DE CERCETARE IBPC-NS: Dr. Irina Titorencu, Dr Ana-Maria Rosca, Dr. Madalina Georgiana Albu-Kaya, Dr. Raluca Tutuianu, Drd. Daniela Madalina Ghetu, As. Constanta Stan, As. Roxana Vladulescu PARTENER: Clinica Zetta RESPONSABIL PARTENER: Prof. Dr. Ana Caruntu
REZUMAT Implantul dentar reprezinta standardul de aur in tratamentul edentatiilor, impedimentul cel mai frecvent intalnit fiind deficitul osos secundar pierderii dintilor. Atrofia osoasa este o problema majora, care impune metode de management specific in vederea reabilitarii implanto-protetice. Scopul proiectului este de a gasi tratamente care combina activitatea antibacteriana cu inducerea repararii tesuturilor osos si gingival prin regenerare ghidata utilizand un substituent 3D spongios format din colagen-doxiciclina-amelogenina (Coll-Dox-Am). Acesta este un biomaterial alternativ cu activitate antibacteriana, care genereaza un micromediu 3D pentru regenerarea osoasa si gingivala in parodontita severa si reconstructia cranio-faciala. Solutia propusa consta in dezvoltarea unui strat dublu Coll-Dox-Am pe baza de colagen extras din somn (Silurus glanis). Primul strat subtire format din colagen-doxiciclina va induce repararea gingiei, inhiband totodata cresterea bacteriilor. Al doilea strat, avand structura 3D, va consta din colagen amestecat cu os de somn decelularizat și amelogenina si va viza refacerea tesutului osos. Aceste doua straturi vor avea viteze diferite de degradare: membrana va fi resorbita dupa 5 zile, fiind prezenta doar in timpul actiunii antibioticului, in timp ce al doilea strat va oferi timp suficient pentru regenerarea osoasa, pana la resorbtia sa completa. Folosind Coll-Dox-Am, sunt asteptate beneficii semnificative pentru sanatatea si bunastarea pacientului. |
ENG
GRANT awarded by the Romanian National Authority for Scientific Research and Innovation PROJECT TYPE: Experimental-demonstrative project PROJECT CODE: PN-IV-P7-7.1-PED-2024-1446 CONTRACT No.: 93/2025 PROJECT TITLE: Innovative antimicrobial collagen based three dimensional scaffolds for craniofacial reconstruction ACRONYM: INNACOLL PERIOD: 6.05.2025-6.05.2027 (24 months) BUGET: 746.162 LEI COORDINATOR: „Nicolae Simionescu“ Institute of Cellular Biology and Pathology (IBPC-NS) PROJECT DIRECTOR: Dr. Irina Titorencu RESEARCH TEAM IBPC-NS: Dr. Irina Titorencu, Dr Ana-Maria Rosca, Dr. Madalina Georgiana Albu-Kaya, Dr. Raluca Tutuianu, Drd. Daniela Madalina Ghetu, As. Constanta Stan, As. Roxana Vladulescu PARTNER: Zetta Clinic PARTNER RESPONSIBLE: Prof. Dr. Ana Caruntu
SUMMARY Implant based tooth replacement became today the gold standard for treating tooth loss, but the main challenge in this treatment is represented by alveolar bone (AB) deficiency. Resorption of AB after dental extraction and implant placement is a serious problem. The project aim is to find solutions for antibacterial treatment and for increasing AB and gingival tissue (GT) repair by guided regeneration using double layer 3D spongious collagen-doxycycline-amelogenin substituent (Coll-Dox-Am). This substitute represents an alternative biomaterial that supports bacterial inhibition and favours a 3D microenvironment for bone and GT regeneration in severe periodontitis and craniofacial reconstruction. The proposed solution consists in the development of a double layer Coll-Dox-Am based on catfish (Silurus glanis) collagen to promote regeneration of AB and GT. The first thin layer made of collagen-doxycycline will induce the development of GT while also inhibiting the growth of bacteria. The second layer with 3D structure will consist of collagen mixed with decellularized catfish bone and amelogenin that will target the restoration of the AB. These two layers will have different degradation rates: the membrane will be resorbed after 5 days, being present only during the antibiotic's action, while the second layer will offer sufficient time for the tissue to heal up to complete resorption. Using Coll-Dox-Am, the significant benefits for the patient’s health and welfare are expected. |
ETAPA 1 - 2025